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Research Scientist II - Cancer Hit Triage

Broad Institute

Research Scientist II - Cancer Hit Triage

Cambridge, MA
Full Time
Paid
  • Responsibilities

    Research Scientist II- Cancer Hit Triage (PRISM) Cambridge, MA/en-US/broad_institute/job/Cambridge-MA/Research-Scientist-I---Hit-Triage_7675/apply Job Description The Broad Institute of MIT and Harvard is looking for an exceptional candidate for a Research Scientist I position in the Cancer Program. This position affords the exciting opportunity to join the PRISM cancer discovery group to lead our Hit Triage team. We are seeking someone to validate hits and to help identify mechanisms of action from the hit compounds from our multiplexed PRISM viability screen. We are seeking an energetic and proactive individual to join our multi-disciplinary group to lead the Hit Triage team and manage junior staff. We are looking for someone with diverse cancer biology experience, to prioritize hit compounds and help identify mechanisms of action using CRISPR modifier screens.nbsp; They would contribute their cancer expertise to our ongoing industrial collaboration utilizing PRISM drug screening technology. The PRISM technology allows us to profile tens of thousands of small molecules against hundreds of cancer cell lines and has enabled data generation at an unprecedented scale. Combined with the wealth of genomic information of these cell lines, we are able to utilize machine learning tools to predict genomic features of sensitivity to compounds. Using CRISPRcas9 genetic modifier screens we are able to identify potential mechanisms of action. We are seeking a talented biologist to help us on this endeavor. In this role, you will identify hits from our large PRISM screens, with support from the team, and validate them by performing viability assays, and apoptosis assays. You will also optimize cell lines and compounds for CRISPR modifier screens as well as develop CRISPRa and CRISPRi screens and identify new technologies and assays to help identify mechanism of action of the hit compounds. You will use deep biological analysis to formulate hypotheses to support the results from the PRISM and genetic modifier screens to prioritize validated hits to our Hit Advancement team. You will have unique skills at rapidly getting up to speed on a diverse portfolio of cancer targets and tools. You will be expected to work independently with guidance from your manager and the project team. Most importantly you will effectively communicate with your team, management and our external collaborators. Duties: * Identifying hits from large scale screen * Perform viability and apoptosis assays * Optimize cell lines for CRISPR genome wide modifier screens * Develop CRISPRa and CRISPRi screens to compare results and technologies * Identify new technologies/ assays to help identify mechanism of action * Deep dive analysis of genetic modifier screens * Prioritize hits and present hypotheses and recommendations from screens to hand off to Hit Advancement team * Work independently and help junior staff Requirements: * Ph.D. or Masters degree with 3+ years of experience in cancer biology and drug discovery * Significant tissue culture and lentiviral infection experience * Extremely strong organizational and time-management skills * Extremely strong communication skills * Demonstrated strong verbal and presentation skills. * The ability to interact professionally with all levels of staff and external collaborators in a fast paced environment. * Must be able to use sound judgment to handle a variety of tasks and to shift priorities simultaneously, as well as to effectively solve problems * Strong analytical skills The successful candidate will be a results-focused, team-oriented, creative cancer biologist able to excel in a fast-track environment. She or he must be self-motivated, detail-oriented and exhibit strong problem solving skills. In addition, the successful candidate should be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with project teams, peers, and management in identifying and achieving research goals. #LI-POST EOE / Minorities / Females / Protected Veterans / Disabilities EEO is The Law - click here for more information Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled Posted 2 Days AgoFull time7675 The Broad Institute is pioneering a new model of collaborative biomedical science to transform biology and medicine. To do that, we have created a unique community of amazing, creative people Broadies each with a passion for pushing scientific frontiers. Broadies have a diverse collection of talents, expertise, and backgrounds, creating a rich collaborative environment for solving intractable scientific problems. We are always looking for new team members within Research, Computational Biology, Software Engineering, and Administration to help us tackle important problems at the cutting edge of science. Why Broad? It comes down to our culture. Our community transcends academic and organizational barriers, encouraging different points of view and making all Broadies part of something meaningful. If ours is a community you would want to be a part of, then please apply! * Return to view all job postings

  • Industry
    Biotechnology