US – SOUTH SAN FRANCISCO, CA

CLINICAL NEXT-GENERATION SEQUENCING DIVISION

The position is based in South San Francisco, CA and is part of the extended Bioinformatics team within the Clinical Next Generation Sequencing Division. The mission of this business unit is to develop next-generation sequencing based solutions to support research applications in oncology and other important unmet medical needs.

HOW WILL YOU MAKE AN IMPACT?

The successful candidate will be part of a multi-disciplinary team responsible for developing and launching cutting edge next-generation sequencing data (NGS) applications for Ion Torrent Sequencing instruments to advance genomic research in oncology and personalized medicine, pharmacogenomics, metagenomics, Immuno-Oncology and other applications.

We're seeking a skilled individual with strong motivation to analyze data, build models, algorithms, and software for analysis of NGS data. The successful candidate will be developing assays for detection of clinically important mutations in cancer (SNVs, indels, CNVs and gene fusions). Specifically, the candidate will develop oncology NGS applications and will prototype, adopt, improve, develop, optimize and validate algorithms and analysis software to analyze DNA/RNA, possibly including cell free DNA (cfDNA) sequencing data for detection of gene fusions, and exon deletions in research samples.

If you are a motivated and innovative bioinformatics scientist seeking to advance your career in these fields, we would like to invite you to join our NGS R&D Bioinformatics team in South San Francisco, CA.

WHAT WILL YOU DO?

• Your primary responsibility is contributing to development, optimization, and validation of state of the art targeted sequencing assays for multiple applications, especially Oncology and Immuno-Oncology, used in research and clinical research settings worldwide.

• You will work on implementing and developing bioinformatics applications of next generation sequencing, including some of the following: detection of known gene fusions, and detection of novel gene fusions, as well as single nucleotide and copy number variation (SNVs and CNVs)

• Collaborate and work closely with molecular biologists, product managers, program managers, other bioinformatics colleagues, and software engineers to build high quality products.

• Communicate your work to colleagues, share your findings, and work with your team to plan and analyze experiments

• Familiarize with production software, and develop tools to facilitate bioinformatics applications

HOW WILL YOU GET HERE?

• PhD/MS programs in computer science, computational biology, biostatistics, bioinformatics, or similar.

• Familiarity with DNA sequencing technologies, genetics, biology, and/or clinical testing.

• Good grasp of statistics and familiarity with Machine Learning concepts is advantageous.

• Familiarity with bioinformatics tools, public genomic resources and genome browsers (UCSC, Ensembl, IGV)

• Strong programming experience on a UNIX platform in at least one programming language such as Python, Java, or similar (higher preference: Python).

• Experience with Matlab or R is desired.

KNOWLEDGE, SKILLS, ABILITIES

• Ability to engage in clear written and oral communication.
• Excellent problem solver, analytic thinker and quick learner
• Familiarity with common bioinformatics tools, high performance computing and understanding of assay design are all highly advantageous.

As the world’s leader in serving science, Thermo Fisher Scientific's professionals develop critical solutions—and build rewarding careers. They help customers in finding cures for cancer, protecting the environment, making sure food is safe, and so much more. When you #StartYourStory with Thermo Fisher, you are guaranteed meaningful work - both personally and professionally.