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Analyst II, Analytical Development

KSQ Therapeutics

Analyst II, Analytical Development

Cambridge, MA
Full Time
Paid
  • Responsibilities

    Job Description

    ABOUT KSQ THERAPEUTICS

    At KSQ Therapeutics, we seek to understand the role of every human gene in each disease, each tissue, and each cell that we study. This comprehensive approach has resulted in a massive, experimentally derived dataset that we have found to be remarkably predictive of past successes and failures in oncology and immuno-oncology product development. Utilizing this approach, we also identified a number of opportunities for the development of new medicines. As a result, we have aggressively invested in these distinct, highly validated pathways for new drug development with the expectation that the medicines we create may become the next breakthrough products for patients.

    Founded in late 2015, KSQ is a preclinical-stage biotech in Kendall Square that has rapidly advanced the field of CRISPR-enabled functional genomics, from in vitro cell autonomous screens to more complex genome-scale screens of immune cells in vivo. The company has expanded the scope of its technology to include multiple cell types and to unlock areas beyond oncology. KSQ is led by a team of accomplished industry experts in drug discovery and development. We maintain a lively and inquisitive environment in the heart of the vibrant Kendall Square (KSQ) neighborhood.

    POSITION SUMMARY:

    Primary duties of this role will focus on the daily lab operations and execution of testing to support process development, stability, and regulatory-enabling studies. Testing may include but is not limited to samples from starting materials, in-process intermediates, final product, and studies using analytical test methods derived from non-compendial sources.

    This role is key to building our analytical development capabilities at KSQ Therapeutics, as it supports our lead cell therapy program. The individual in this role will join our growing Quality & Technical Operations team.

    Duties/Responsibilities:

    • Develop, refine, and/or qualify advanced analytical methods for cell therapy products and starting materials to measure key quality attributes to support process development, product characterization, and QC release testing.
    • Execute analytical test methods to support process development, stability studies and regulatory-enabling studies.
    • Prepare and present technical data, technical reports, and standard operating procedures (SOPs) for internal use and transfer to external sites.
    • Trend control, stability, and release data.
    • Provide technical support to cross-functional groups and external collaborators.
    • Evaluate new analytical platforms, and stay up to date on state-of-the-art methodologies.

    REQUIREMENTS

    • Minimum of a BS in Biology, Chemistry, or related scientific discipline
    • 3-5 years of bench experience in the pharma or biotech industry
    • Hands-on experience in PCR, Flow Cytometry, Cell Culture (NGS is a plus)
    • Excellent laboratory, computer, documentation, and organization skills
  • Industry
    Biotechnology