NIH-funded postdoctoral positions are available in the laboratory of Benjamin Wolozin to study the molecular basis of neurodegenerative disease. The laboratory investigates the role of RNA binding proteins in the pathophysiology of neurodegenerative diseases, including Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and Parkinson's disease.
Current studies characterize the protein interaction and RNA interaction networks in the context of the disease stress response, RNA granules, and pathological complexes (e.g., tau, TIA1, TDP-43). An important goal is to understand how the complexes change with disease, identify which are the crucial modulators of each type of complex, and identify methods of intervention to normalize the disease-related changes of these complexes. We are keen to analyze these networks in a cell type-specific manner, investigating the specific biologies of neurons, microglia, astrocytes, and the neurovascular unit in the context of disease.
The work employs multiple advanced technologies including proteomics (proximity profile labeling, protein::protein interaction networks), genomics (scRNAseq, CLiPseq, etc), RNA metabolism (RNA modifications, RNA splicing, circRNA, BOBCAT, SunSET, translational control), synthetic biology, live-cell imaging, and immunochemical approaches. The laboratory utilizes human tissues, animal models, and human brain organoids.
About the employer:
The laboratory is well funded and positions are available immediately. Boston University School of Medicine is located in the heart of one of the world’s most vibrant biotechnology communities. The laboratory is a moderate-sized lab (~10 people), with 2200 square feet of space, with all necessary resources.
The highest priority will be given to candidates who are about to finish their Ph.D. or within 1 year of finishing their Ph.D. (i.e., early postdocs). For more information, visit the Wolozin Lab website: http://www.bumc.bu.edu/busm-pm/research/laboratories/wolozinlab/
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