Job Description

Position Summary

We are seeking a highly skilled and motivated Organic Chemist with expertise in oligonucleotide synthesis and purification to support process development and manufacturing. This role focuses on developing, optimizing, and scaling chemical processes for high-throughput and high-quality oligonucleotide production.

Key Responsibilities

• Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides

• Process development and scale-up from R&D to manufacturing

• Develop and improve oligonucleotide purification processes (e.g., HPLC, ion-exchange, desalting)

• Troubleshoot synthesis and purification challenges to improve yield and purity

• Collaborate with manufacturing, QC, and engineering for process transfer

• Evaluate new chemistries and technologies

• Author SOPs, batch records, and technical reports

• Ensure compliance with quality systems

• Mentor lab technicians

Qualifications

Qualifications

• Ph.D. or Master’s degree in Organic Chemistry or related field (required)

• Minimum 5 years of industrial experience in chemical synthesis or open to a recent PhD graduate

• Experience with solid-phase oligonucleotide synthesis

• Experience in oligonucleotide purification process development

• Strong analytical skills (HPLC, LC-MS)

• Experience scaling processes to manufacturing

Preferred Qualifications

• Experience in GMP or regulated environments

• Familiarity with automated DNA/RNA synthesizers

• Knowledge of modified nucleotides

• Experience in high-throughput oligo production

Work Environment

• Fast-paced, collaborative environment

• Ability to manage multiple priorities

• Occasional off-hours support as needed

Work Schedule

Location: Louisville, KY

Schedule: Monday–Friday, 8:00 AM – 5:00 PM

Weekend Work as needed

Additional Information

All your information will be kept confidential according to EEO guidelines.