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Janssen Research and Development, L.L.C., a member of Johnson and Johnson's Family of Companies, is recruiting for a Postdoctoral Fellow in BioTherapeutics Development and Supply – Active Pharmaceutical Ingredient (API), located in Malvern, PA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found.

Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases.

The Biotherapeutics Development-Active Pharmaceutical Ingredient (BioTD-API) develops creative large molecule solutions to address significant unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. The API Process Development organization is continuing to build key scientific expertise in metabolic and process modeling. The Postdoctoral Scientist will be responsible for leading a collaborative project to build a digital twin model of Janssen’s upstream platform process. The goal of the project is to create an accurate, genome-based model that will serve as a digital representation of large scale-production reactors, and to use the model to guide upstream process development from cell line selection through the production bioreactor.

Responsibilities:

• Expand cutting-edge modeling capabilities by incorporating new technology, process improvements and product quality into genome-scale metabolic model
• Work with cross-functional team to define, build and/or improve data processing workflows (data collection, aggregation, cleaning, etc.)
• Assist CMC project teams in building models of their cell culture process to aid teams in process design
• Use, or improve, orthogonal models to serve as a cross-check that model outputs are accurate
• Perform statistical analyses on model outputs to assess accuracy of model parameters
• Develop standardized workflows to allow the model to be used by a wide user group with varying abilities

Requirements:

• A Ph.D. in Chemical Engineering, Biomedical Engineering, Computer Science or related field
• Experience with programming languages such as Java, Python, C/C++ or similar is highly preferred
• Experience with cell culture and cell metabolism is highly preferred
• Experience with quantitative analysis of metabolic pathways, specifically flux balance analysis is highly preferred
• A proven ability to develop and execute experimental protocols as well as analyze and properly interpret data is a must
• Strong oral and written communication skills
• A strong commitment to good documentation practices a must

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Push the boundaries of science to transform health—and your career.

Join us and advance life-changing treatments for people who need them most. At Johnson & Johnson, our focus is on improving global health equity and developing MedTech and pharmaceutical innovations that impact the future of health. Using AI and robotics to transform surgery or helping data scientists and clinicians formulate new ways to diagnose and treat disease, this work may sound like sci-fi, but it’s all science, all real, and could be your career. Whatever your background, skills, or career goals, there’s a place for you to help solve some of the world’s most pressing health challenges with us.

Accelerate your career while changing the world.

Each of our broadly-based family of companies offers an inclusive and empowering culture and employee benefits (like paid time off to volunteer, transgender-inclusive and same-sex partner health insurance coverage, and more) designed to help you live your best life, however you define it. And our best-in-class learning and development approaches, mentorship, and access to innovators across the world will help you grow your skills and reach your career goals. Because when you're at your best, nothing stands between you and your next breakthrough.