This Co-op position offers an exciting opportunity to contribute to the innovative research in the Cell Therapy Formulation group, a part of the Drug Product Development department at Janssen R&D. The Co-op will be working at the intersection of molecular/cell biology and process development with the goal of enhancing cell therapy robustness to formulation and cryopreservation stresses. The Co-op will also be involved in supporting additional internal innovation and process development studies. In addition, the Co-op will gain exposure to CAR-T characterization and potency assay, as well as understanding of different aspects of cell therapy process development and formulation.

In this position the Co-op student will:

• Design and execute studies to test effects of cell therapy product and process modifications on drug product robustness to chemical and thermal stresses

• Design and screen a molecular construct library under different process conditions

• Perform cell characterization studies which include but are not limited to flow cytometry, imaging, and potency assays

• Perform transfection, electroporation and/or viral transduction of cells

• Perform supporting duties, which include cell culture, reagent preparation, and other laboratory operational support

• Troubleshoot technical difficulties in experimental procedures, assays, and data analysis

• Design and clone novel molecular constructs

• Author technical reports and present data to colleagues and functional line management

• Collaborate with functional line management as well as scientists in related functional areas such as Active Pharmaceutical Ingredient (API) team, Analytical Development (AD), Manufacturing, QC/QA, Clinical, Toxicology, and Regulatory (CMC)

• Perform duties consistent with good laboratory practices including careful documentation in an electronic laboratory notebook

QUALIFICATIONS

• Progress towards B.S. (Senior level), M.S. or Ph.D. degree in molecular biology, biomedical engineering, chemical engineering, bioengineering, pharmaceutical sciences, biophysics, biochemistry, immunology, or a related field

• Extensive experience with molecular biology techniques which include plasmid transfection, lenti- or retrovirus production, and viral transduction

• Demonstrated ability to perform aseptic mammalian cell culture

• Experience with flow cytometry and fluorescent imaging techniques

• Strong skills in statistical data analysis

• A self-starter individual capable of troubleshooting technical issues

• A strong record of work experience and accomplishment in research labs

• Excellent written and verbal communication skills

PREFERRED QUALIFICATIONS:

• An M.S or a PhD degree candidate

• Experience with viral vector design and molecular cloning techniques

• Extensive experience with flow cytometry and FlowJo data analysis

• Experience with protein design and bioinformatic protein analysis

• Knowledge of T cell biology, T cell characterization, and functional assays

• Experience with cell engineering techniques

• Excellent track record of peer-reviewed publications

At Johnson & Johnson, we’re on a mission to change the trajectory of health for humanity. That starts by creating the world’s healthiest workforce. Through cutting-edge programs and policies, we empower the physical, mental, emotional and financial health of our employees and the ones they love. As such, candidates offered employment must show proof of full COVID-19 vaccination or secure an approved accommodation prior to the commencement of employment to support the well-being of our employees, their families and the communities in which we live and work.

For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

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