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CompChem/ML Summer 2023 Intern

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Johnson & Johnson

Johnson & Johnson

CompChem/ML Summer 2023 Intern

San Diego, CA
Internship
Paid
  • Responsibilities

    Janssen Research & Development, L.L.C. develops treatments that improve the health and lifestyles of people worldwide. As a leading pharmaceutical company in the United States, we focus our innovation on some of the most devastating diseases and the most complex medical challenges of our time, across six therapeutic areas: Cardiovascular & Metabolism, Immunology, Infectious Diseases & Vaccines, Neuroscience, Oncology and Pulmonary Hypertension. For more about Janssen Pharmaceuticals, Inc., Pharmaceutical Companies of Johnson & Johnson, visit www.janssen.com (http://www.janssen.com)

    The In Silico Discovery (Computational Chemistry) Group in La Jolla, CA is seeking a current PhD student for a 10-12 week summer research internship. We are looking for a knowledgeable, self-motivated, creative, and multi-skilled computational chemistry student with a strong interest in machine-learning. In this position, the intern will apply a variety of cheminformatics, machine-learning, and virtual screening strategies for efficiently screening ultra-large virtual molecular libraries such as Enamine REAL-which currently holds ~5.5 billion compounds.

    You will develop a strategic computational workflow which will apply a combination of docking and machine learning techniques to identify potent & diverse chemical matter from ultra-large virtual libraries within a short time frame (i.e. days). The models generated from this workflow can then be used to speed up early stages of drug discovery by quickly searching virtual chemical spaces and finding valuable compounds for further evaluation by medicinal chemists. There will be an opportunity to test this strategy and the generated models predictions on real live projects within Janssen which, if successful, could have an impact on the direction of the project and can lead to a valuable tool for application to other projects.

    Qualified candidates should have strong interpersonal & analytical skills and are excited to share their own creative ideas to solve this challenge in new ways.

    QUALIFICATIONS

    • Pursuing a PhD in a relevant field including computational chemistry, cheminformatics, data science, machine-learning, or a related field required.

    • Documented coursework, training, or certification in basic (intro-level) machine-learning required.

    • Proficiency in coding in python and basic scripting in bash/shell required.

    • Familiarity with python libraries such as pandas, jupyter, rdkit, and scikit-learn preferred.

    • Experience using common docking tools such as GLIDE (Schrodinger), FRED (OpenEye), DOCK, or AutoDock/Vina preferred.

    WAYS TO STAND OUT:

    • Documented track record of research productivity by publications and/or Github repositories.

    • Experience in using the python APIs for: Schrodinger, OpenEye, DeepChem, or ChemProp

    • Knowledge in active learning strategies for machine learning

    At Johnson & Johnson, we're on a mission to change the trajectory of health for humanity. That starts by creating the world's healthiest workforce. Through cutting-edge programs and policies, we empower the physical, mental, emotional and financial health of our employees and the ones they love. As such, candidates offered employment must show proof of full COVID-19 vaccination or secure an approved accommodation prior to the commencement of employment to support the well-being of our employees, their families and the communities in which we live and work.

    For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com

    Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

  • Industry
    Hospital and Health Care
  • Fun Fact
    We aspire to be the world's healthiest work force, offering group fitness classes, beach volleyball courts, bicycle desks, and more!
  • About Us

    Push the boundaries of science to transform health—and your career.

    Join us and advance life-changing treatments for people who need them most. At Johnson & Johnson, our focus is on improving global health equity and developing MedTech and pharmaceutical innovations that impact the future of health. Using AI and robotics to transform surgery or helping data scientists and clinicians formulate new ways to diagnose and treat disease, this work may sound like sci-fi, but it’s all science, all real, and could be your career. Whatever your background, skills, or career goals, there’s a place for you to help solve some of the world’s most pressing health challenges with us.

    Accelerate your career while changing the world.

    Each of our broadly-based family of companies offers an inclusive and empowering culture and employee benefits (like paid time off to volunteer, transgender-inclusive and same-sex partner health insurance coverage, and more) designed to help you live your best life, however you define it. And our best-in-class learning and development approaches, mentorship, and access to innovators across the world will help you grow your skills and reach your career goals. Because when you're at your best, nothing stands between you and your next breakthrough.