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Job Function:

Career Programs

Job Sub Function:

Non-LDP Intern/Co-Op

Job Category:

Career Program

All Job Posting Locations:

Malvern, Pennsylvania, United States of America

Job Description:

This project will study effect of different real-world stresses on drug products in the J&J portfolio. Experiments will be designed and executed to mimic the intensity and duration of agitation that protein formulations experience during transportation in vials, IV bags, and syringes. A fundamental understanding of the impact of physical stresses on protein formulations will be gained by a thorough literature review as well as experimental data collection.

A safe and effective drug product must be able to withstand a variety of different forces experienced during shipping, preparation, and administration. These forces include shear stress, mixing stresses, impact stresses (i.e. drop stress), and cavitation. Therapeutic proteins are inherently sensitive to these stresses and may form insoluble aggregates that can impact patient safety. During formulation selection, drug products are exposed to some of these stresses in bench-top shaking studies, however there is little understanding of how well these lab-based studies mimic the stresses during real shipping and transport. New studies have provided measurements of the duration and intensity of the real-world stresses experienced during transportation and have they depend on the acceleration and geometric orientation of the stress relative of the drug product. All of these stresses cannot be captured on a standard bench-top shaking plate, therefore a gap exists between developmental studies and real-world. This project will include the design of new bench-top studies in order to separately study the effects of mixing stress, shear stress, extensional stress and air-entrainment and utilization of particle characterization tools like dynamic light scattering (DLS), Flowcam, and MFI. By developing a comprehensive stress-specific framework for studying protein formulations, a better understanding of how different real world stresses impact drug product stability can be captured. The findings and outcomes from this project will be leveraged across all protein formulations for conducting shaking studies to ensure product stability and patient safety.

Majors: Chemistry, Chemical Engineering, Pharmaceutical Sciences, Biochemistry, Biomedical Engineering

Prerequisites (prior experience, demonstrated expertise, educational level): Previous lab experience is required for at least 6 months combined. Rising junior in undergraduate would be minimum education level but graduate student would also be acceptable.

Permanently authorized to work in the U.S., must not require sponsorship of an employment visa (e.g., H-1B or green card) at the time of application or in the future. Students currently on CPT, OPT, or STEM OPT usually requires future sponsorship for long term employment and do not meet the requirements for this program unless eligible for an alternative long-term status that does not require company sponsorship.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

_Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via _https://www.jnj.com/contact-us/careers . internal employees contact AskGS to be directed to your accommodation resource.

Required Skills:

Preferred Skills:

Push the boundaries of science to transform health—and your career.

Join us and advance life-changing treatments for people who need them most. At Johnson & Johnson, our focus is on improving global health equity and developing MedTech and pharmaceutical innovations that impact the future of health. Using AI and robotics to transform surgery or helping data scientists and clinicians formulate new ways to diagnose and treat disease, this work may sound like sci-fi, but it’s all science, all real, and could be your career. Whatever your background, skills, or career goals, there’s a place for you to help solve some of the world’s most pressing health challenges with us.

Accelerate your career while changing the world.

Each of our broadly-based family of companies offers an inclusive and empowering culture and employee benefits (like paid time off to volunteer, transgender-inclusive and same-sex partner health insurance coverage, and more) designed to help you live your best life, however you define it. And our best-in-class learning and development approaches, mentorship, and access to innovators across the world will help you grow your skills and reach your career goals. Because when you're at your best, nothing stands between you and your next breakthrough.