Janssen Research & Development, L.L.C, a Johnson & Johnson's company, is recruiting for a Post Doctoral Fellow, Pharmacometrics, at its Spring House PA, Raritan NJ, Titusville NJ, La Jolla, CA.

Janssen Research & Development develops treatments that improve the health and lifestyles of people worldwide. Research and development areas encompass novel targets in oncology, immunology, neurologic disorders, cardiovascular/metabolic disorders, and infectious disease. Clinical Pharmacology and Pharmacometrics (CPP) is integrated with Statistics and Decision Science in the Scientific Core of Quantitative Sciences as a single aligned organization as part of Janssen Research & Development. We work in cross-disciplinary Quantitative Sciences teams and apply quantitative principles across the R&D portfolio to enable optimal decision-making at the earliest time point and in the most efficient manner.

The Post-Doctoral Fellow will be involved in various activities to support Research and Development in areas ranging from preclinical to early/late stage clinical development, including:

CLINICAL PHARMACOLOGY & PHARMACOMETRICS

The Clinical Pharmacology and Pharmacometrics (CPP) department at Janssen R&D (JRD) develops and applies quantitative methodologies (population pharmacokinetics, mixed effects modeling, PK/PD analysis, and disease progression modeling) across all phases of drug development. CPP is sponsoring a Post-Doctoral Fellow in its newly developed Clinical Pharmacology and Pharmacometrics Fellowship Program to train early career professionals who can contribute to our goal of discovering and developing innovative medicines. The Post-Doctoral Fellow will work on one or multiple projects to apply and expand in-house clinical pharmacology knowledge, exposure-response, PK/PD, and/or QSP modeling platforms to inform decision making in drug development such as dose selection, and applying model informed drug development (MIDD) principles. This Post-Doctoral Fellow is expected to have recently finished his/her PhD training. The Post-Doctoral Fellow will work under one or more scientists who will provide mentorship during the 2-year program.

EXAMPLES OF THE ACTIVITIES INCLUDED IN THE SCOPE OF THE POSITION ARE LISTED BELOW. FELLOW ACTIVITIES WILL BE CONDUCTED UNDER THE GUIDANCE AND MENTORSHIP OF AN ASSIGNED PRECEPTOR:

• Advance the development of fit-for-purpose mathematical models (eg, population PK and PK/PD, empirical or mechanism-based PK/PD, quantitative systems pharmacology) to inform clinical study design (including but not limited to human PKPD analysis, first-in-human (FIH) starting dose projection, and efficacious dose selection) through identifying and addressing critical knowledge gaps using modeling and simulation approaches
• Develop flexible tools for data visualization, pharmacometrics analysis and report automation and standardization
• Identify and improve processes and workflow, develop innovative thinking, inform strategic decision making, and implement new methodologies when applicable

• A PhD in Pharmacology, Pharmacokinetics, Pharmaceutical Sciences, Biostatistics, Engineering, Bioinformatics, Computer Science, Applied Mathematics, Systems Biology, or Computational Biology
• Demonstrated computational skills related to pharmaceutical or biomedical research, and strong hands-on programming skills in R is required; experiences with additional PKPD modeling tools are desired
• Excellent interpersonal skills with an ability to build positive relationships with colleagues from a diverse set of backgrounds and work with senior members and cross-functional teams
• Detail-oriented, highly organized, and able to manage multiple tasks
• Ability to function in a fast-paced environment and a creative problem solver

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

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