POST-DOCTORAL FELLOW, SYNAPTIC PLASTICITY IN BRAIN PHYSIOLOGY AND DISEASE
At Johnson & Johnson, we use technology and the power of teamwork to discover new ways to prevent and overcome the world’s the most significant healthcare challenges. Our Corporate, Consumer Health, Medical Devices, and Pharmaceutical teams leverage data, real-world insights, and creative minds to make life-changing healthcare products and medicines. We're disrupting outdated healthcare ecosystems and infusing them with transformative ideas to help people thrive throughout every stage of their lives. With a reach of more than a billion people every day, there’s no limit to the impact you can make here. Are you ready to reimagine healthcare?
Here, your career breakthroughs will change the future of health, in all the best ways. And you’ll change, too. You’ll be inspired, and you’ll inspire people across the world to change how they care for themselves and those they love. Amplify your impact. Join us!
The Neuroscience Team in La Jolla, California discovers medicines to treat neuropsychiatric diseases – especially disorders of mood and cognition. Our discovery strategy focuses in part on the emerging pharmacology of synaptic receptors and their associated subunits. We are seeking a highly-motivated Postdoctoral Fellow to develop this exciting science. The Postdoctoral Fellow will employ biochemical and genetic strategies to elucidate the molecular composition and plasticity of neuronal glutamate and nicotinic receptor complexes. This will enable discovery of new drug targets and interrogation of their roles with transgenic models and pharmacological agents. This science will interface with Janssen’s medicinal chemistry, biochemical screening and molecular neurobiology teams. This special opportunity allows the Fellow to perform and publish cutting-edge basic science while benefiting from the resources and technologies of a pharmaceutical company.
As a post-doctoral fellow you will:
Maher et al. Getting a Handle on Neuropharmacology by Targeting Receptor-Associated Proteins Neuron 2017 96:989-1001.
Gu et al. α6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components. Cell Rep_orts_ 2019 26:866-874
Dawe et al. α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins. Nature Communications 2019 10:2746
Dhara et al. Polyamine regulation of ion channel assembly: implications for nicotinic acetylcholine receptor pharmacology Nature Communications 2020 11: 2799
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