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Postdoctoral Fellow, Computational Biology and Toxicology

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Johnson & Johnson

Johnson & Johnson

Postdoctoral Fellow, Computational Biology and Toxicology

San Diego, CA
Full Time
Paid
  • Responsibilities

    At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

    A grand challenge for toxicogenomics (TGx) is the development of accurate predictions of toxicology outcomes from gene expression changes. Unraveling the relationship requires sufficient levels of information to appropriately categorize the toxicological outcomes and the focused gene signatures. Academia and consortia quests are often constrained by having limited published data sets. Janssen is in a unique position of having a significant number of internal compounds with both TGx data and extensive toxicology information. Drug compounds inducing similar apical toxicity endpoints, such as drug-induced liver injury (DILI), may have a variety of mechanisms and molecular initiating events (MIE), therefore generate diverse gene expression changes that do not share a common gene signature. We will apply proprietary methods to further categorize internal and external compounds of the same toxicities, then assess the possibility to develop transcriptomic biomarkers for each molecular mechanism of a toxicity.    

    This position will collaborate with cross functional scientists in multiple disciplines, including computational biology, quantitative sciences, pathology, toxicology, and others. This project aims to identify gene signatures for toxicities common to Janssen compounds, develop an analysis workflow for toxicology studies, and publish novel findings.

    RESPONSIBILITIES:

    • Summarize toxicity findings and prioritize the ones common to Janssen compounds and having abundant inter and external data

    • Identify and categorize molecular mechanisms of selected toxicities

    • Identify gene signatures of each toxicity mechanisms

    • Validate gene signatures and develop predictive methods

    QUALIFICATIONS

    REQUIRED:

    • Required Minimum Education:  PhD in Computational Biology, Systems Biology, Biostatistics, or a related discipline

    • Proficiency in microarray, RNA-Seq, and other genomics data analysis

    • Proficiency in statistical analysis, preferably using R

    • Experience with toxicogenomics and other toxicology data analysis and interpretation

    • Excellent communication, reporting and writing skills

    • Excellent team player and collaborator, a self-starter and quick learner. Ability to work independently

    PREFERRED:

    • Experience with data management and computing in a cloud environment

    • Experience with large scale data collection, processing, integration, and meta-analysis

    • Familiarity with toxicology principles and a reasonable understanding of pathology

    • Understanding of and familiarity with toxicology outcomes

    PRIMARY LOCATION

    United States-California-San Diego-3210 Merryfield Row

    ORGANIZATION

    Janssen Research & Development, LLC (6084)

    JOB FUNCTION

    R&D

  • Industry
    Hospital and Health Care
  • Fun Fact
    We aspire to be the world's healthiest work force, offering group fitness classes, beach volleyball courts, bicycle desks, and more!
  • About Us

    Push the boundaries of science to transform health—and your career.

    Join us and advance life-changing treatments for people who need them most. At Johnson & Johnson, our focus is on improving global health equity and developing MedTech and pharmaceutical innovations that impact the future of health. Using AI and robotics to transform surgery or helping data scientists and clinicians formulate new ways to diagnose and treat disease, this work may sound like sci-fi, but it’s all science, all real, and could be your career. Whatever your background, skills, or career goals, there’s a place for you to help solve some of the world’s most pressing health challenges with us.

    Accelerate your career while changing the world.

    Each of our broadly-based family of companies offers an inclusive and empowering culture and employee benefits (like paid time off to volunteer, transgender-inclusive and same-sex partner health insurance coverage, and more) designed to help you live your best life, however you define it. And our best-in-class learning and development approaches, mentorship, and access to innovators across the world will help you grow your skills and reach your career goals. Because when you're at your best, nothing stands between you and your next breakthrough.