Postdoctoral Fellow, DNA-Encoded Library Technology

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Johnson & Johnson

Johnson & Johnson

Postdoctoral Fellow, DNA-Encoded Library Technology

La Jolla, CA
Full Time
Paid
  • Responsibilities

    Janssen, a member of Johnson & Johnson's Family of Companies, is recruiting a talented organic chemist in our laboratories in La Jolla, CA, for the position of POSTDOCTORAL FELLOW - DNA-ENCODED LIBRARY TECHNOLOGY (DELT). You will identify, develop and apply novel chemical transformations which are compatible with DNA-encoded library (DEL) synthesis to fully leverage the power of DEL in Hit/Lead Discovery. You will collaborate closely with other functional areas in Discovery Chemistry and Lead Discovery, and with external CROs and research institutions to develop next generation DEL technology. In this role, you will also have the opportunity to learn medicinal chemistry and other drug discovery technologies within Janssen.

    The Postdoctoral Fellow - DNA-Encoded Library Technology (DELT) will:

    • Develop novel DEL compatible transformations through the application of modern catalysis, such as C-H functionalization, photoredox catalysis and biocatalysis
    • Demonstrate the application of these novel chemistries in DEL library design and synthesis sequences
    • Collaborate closely with Lead Discovery team to expand the DEL screen beyond the affinity-based selection
    • Present and/or publish research results at internal/external meetings, and peer-reviewed journals
  • Qualifications
    • Candidates must have a Ph.D. degree in Chemistry in an accredited college/university, or expecting a Ph.D. degree in 2020
    • Candidates must be available to work full-time.
    • Experience with DNA-encoded library design, reaction development, library synthesis and successful application of DELT in drug discovery is a plus
    • Strong track record of scientific contributions including peer reviewed first-author publications, patent applications, and presentations at major national meetings is required
    • Strong problem-solving skills for developing creative and innovative solutions are required
    • Experience with lab automation is preferred
    • Experience with modern cheminformatics, computational tools and scientific software in chemistry, and the ability to apply data-mining, data visualization and other techniques to complex datasets is preferred
    • Demonstrated leadership is preferred.
    • Candidates must be detail-oriented, highly organized and able to manage multiple tasks.
    • Candidates must have the ability to work individually (independently) as well as on a team.
    • Candidates need to be proficient with Microsoft Office, Word, Excel (including a high proficiency with generating pivot tables and graphs), and Power Point, and have strong oral and written communication skills.
    • A minimum G.P.A. of 3.0 is strongly preferred.

    We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

  • Industry
    Hospital and Health Care
  • Fun Fact
    We aspire to be the world's healthiest work force, offering group fitness classes, beach volleyball courts, bicycle desks, and more!
  • About Us
    When you join Johnson & Johnson, your next move could mean the next innovation. In the next ten years, healthcare is predicted to radically transform more than any other industry, with old models being disrupted in favor of new methods to make the world a healthier place for everyone. Johnson & Johnson has long excelled in times of transformation. Its history of firsts—from Band-Aids to feminine care to treatments for HIV, cancer, Ebola, and, most recently, Alzheimer’s — demonstrates how J&J combines passion, science and technology to create game-changing innovations. Those epic innovations were discovered, developed and distributed by people just like you. And when you apply your talent to Johnson & Johnson's shared purpose, there’s no end to the lasting impact you can make, together. And that changes everything.