Description

At Johnson & Johnson Innovative Medicine, we use technology and the power of teamwork to discover new ways to prevent and overcome the world’s the most significant healthcare challenges. Our Corporate, Pharmaceutical and Medical Devices teams leverage data, real-world insights, and creative minds to make life-changing healthcare products and medicines. We're redefining outdated healthcare ecosystems and infusing them with transformative ideas to help people thrive throughout every stage of their lives. With a reach of more than a billion people every day, there’s no limit to the impact you can make here. Are you ready to reimagine healthcare?

Here, your career breakthroughs will change the future of health, in all the best ways. And you’ll change, too. You’ll be inspired, and you’ll inspire people across the world to change how they care for themselves and those they love. Amplify your impact. Join us!

The Post-doctoral Research Scientist-Oncology Discovery Hematological Malignancies [focused on Multiple Myeloma (MM)] will work independently on a project designed to further the understanding of MM and hematological malignancy biology with the goal of investigating mechanisms of T cell engager resistance. You will have the ability to work with and learn from experts within discovery oncology research, specialized in cell and molecular biology, flow cytometry, computational biology, and in vivo sciences, while also leveraging additional resources at J&J Innovative Medicine. The length of the position will be 2 years, the candidate is expected to present and publish their research.

In this role you will:

• Work with discovery scientists within J&J Innovative Medicine to design and execute studies to further our understanding of mechanisms of resistance to T cell redirection therapeutics (ie. Bispecific/multispecific antibodies and CART), with a focus on the multiple myeloma (MM) disease area
• Integrate internal and external data in the design and interpretation of experiments
• Develop and utilize assays to mimic bone marrow-like conditions
• Investigate MM protein biology
• Use CRISPR/Cas9 screening technologies
• Design and analyze multi-color (6-16) flow cytometry experiments to characterize immune cell function (e.g., celesta, fortessa, symphony)
• Perform advanced molecular and cellular biology techniques (e.g., viral and non-viral cell transduction, Western blot, DNA/RNA isolation, and qRT-PCR)
• Perform functional T cell redirection assays using bispecific/multispecific antibodies and CART cell therapy
• Maintain detailed and organized experimental records and stay compliant on all relevant internal and external training requirements
• Communicate scientific results to multidisciplinary teams including computational biologists, bench scientists, clinicians, and management in an appropriate biological context

Qualifications

• A Ph.D. in cell and/or molecular biology, oncology, immunology, biochemistry, microbiology, or related field received in the last 0-3 years or by the start of this position.
• Expertise in the oncology area - including tumor biology, signaling, immuno-oncology, T cell redirection (antibody or cell therapy).
• MM biology and T cell engagement experience is preferred but not necessary
• Basic understanding of bioinformatics and/or RNA sequencing is preferred but not necessary
• Strong publication record demonstrating relevant experience
• Strong communication AND collaboration skills required with a One-Team focused approach
• Must be legally authorized to work in the U.S. for the full duration of the role

The base salary for this position is $95,000/year. This position is eligible for a sign-on bonus.

The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year. Bonuses are awarded at the Company’s discretion on an individual basis.

Employees may be eligible to participate in Company employee benefit programs such as health insurance, savings plan, pension plan, disability plan, vacation pay, sick time, holiday pay, and work, personal and family time off in accordance with the terms of the applicable plans. Additional information can be found through the link below.

For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits

Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Push the boundaries of science to transform health—and your career.

Join us and advance life-changing treatments for people who need them most. At Johnson & Johnson, our focus is on improving global health equity and developing MedTech and pharmaceutical innovations that impact the future of health. Using AI and robotics to transform surgery or helping data scientists and clinicians formulate new ways to diagnose and treat disease, this work may sound like sci-fi, but it’s all science, all real, and could be your career. Whatever your background, skills, or career goals, there’s a place for you to help solve some of the world’s most pressing health challenges with us.

Accelerate your career while changing the world.

Each of our broadly-based family of companies offers an inclusive and empowering culture and employee benefits (like paid time off to volunteer, transgender-inclusive and same-sex partner health insurance coverage, and more) designed to help you live your best life, however you define it. And our best-in-class learning and development approaches, mentorship, and access to innovators across the world will help you grow your skills and reach your career goals. Because when you're at your best, nothing stands between you and your next breakthrough.