At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biological Research

Job Category:

Scientific/Technology

All Job Posting Locations:

Cambridge, Massachusetts, United States of America

Job Description:

About Innovative Medicine
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Principal Scientist, Viral Vectors (Cell and Genetic Medicines Discovery) to be located in Cambridge, MA.

Purpose:

We are seeking a highly motivated and experienced scientist to join our CAR-T cell therapy discovery efforts as a Principal Scientist. In this role, you will play a key part in advancing our research initiatives by leveraging your expertise in viral vectors and molecular biology. This position presents a unique opportunity to contribute to groundbreaking research in CAR-T cell therapy. If you are passionate about advancing scientific discovery and possess a collaborative mindset, we invite you to apply!

You will be responsible for:

• Utilize your extensive knowledge in vector engineering, virology, and molecular biology to drive groundbreaking research in our cell therapy platform and pipeline development.

• Design, develop, and implement novel methodologies for vector targeting, packaging, and analytical characterization, including assays for vector quantification, potency, and purity.

• Lead efforts in troubleshooting and refining viral vector quantification techniques such as PCR-based assays, flow cytometry, and vector copy number (VCN) analysis, ensuring robust and reproducible data.

• Drive continuous improvement of vector production platforms, including titers, purity, and scalability, to enhance overall process efficiency.

• Maintain expertise and provide innovative solutions to complex research challenges

• Initiate and foster collaborative projects with internal cross-functional teams, external partners, and academic institutions to accelerate innovation and knowledge sharing.

• Present complex data insights to diverse audiences, including research teams and senior leadership, to inform strategic decision-making and project direction.

• Deliver high-quality results within established timelines, demonstrating ownership and accountability for scientific milestones.

• Ensure compliance with Good Laboratory Practices (GLP) and Environmental Health and Safety (EHS) protocols.

Qualifications:

• Ph.D. in a relevant field; OR a Master's or Bachelor’s degree with 6-8 years of extensive experience.

• Extensive hands-on expertise in enveloped viruses, viral vector engineering, production, and characterization; lentiviral vectors preferred.

• Proven track record in exploratory science with a strong bench science background and willingness to perform experimental work.

• Deep knowledge of molecular and cellular biology techniques, cell culture, flow cytometry, and high-throughput workflows.

• Demonstrated ability to develop innovative solutions, troubleshoot complex problems, and optimize processes.

• Highly organized, detail-oriented, with excellent multitasking skills and the ability to operate independently.

• Strong collaborative skills and experience working effectively within multidisciplinary teams.

• Excellent scientific communication skills, including technical writing and presentation abilities tailored for diverse audiences.

• Commitment to maintaining accurate, detailed records and ensuring reproducibility of experiments.

• Up to 5-10% travel is required.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource.

The anticipated base pay range for this position is :

$115,000 to $197,800

Additional Description for Pay Transparency:

The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year. Bonuses are awarded at the Company’s discretion on an individual basis. • Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. • Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)). • Employees are eligible for the following time off benefits: • Vacation – up to 120 hours per calendar year • Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington – up to 56 hours per calendar year • Holiday pay, including Floating Holidays – up to 13 days per calendar year of Work, Personal and Family Time - up to 40 hours per calendar year • Additional information can be found through the link below. https://www.careers.jnj.com/employee-benefits The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market.

Push the boundaries of science to transform health—and your career.

Join us and advance life-changing treatments for people who need them most. At Johnson & Johnson, our focus is on improving global health equity and developing MedTech and pharmaceutical innovations that impact the future of health. Using AI and robotics to transform surgery or helping data scientists and clinicians formulate new ways to diagnose and treat disease, this work may sound like sci-fi, but it’s all science, all real, and could be your career. Whatever your background, skills, or career goals, there’s a place for you to help solve some of the world’s most pressing health challenges with us.

Accelerate your career while changing the world.

Each of our broadly-based family of companies offers an inclusive and empowering culture and employee benefits (like paid time off to volunteer, transgender-inclusive and same-sex partner health insurance coverage, and more) designed to help you live your best life, however you define it. And our best-in-class learning and development approaches, mentorship, and access to innovators across the world will help you grow your skills and reach your career goals. Because when you're at your best, nothing stands between you and your next breakthrough.