At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Pharmacokinetics & Pharmacometrics

Job Category:

Scientific/Technology

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Scientist, Bioanalysis – Target Engagement to be onsite in Spring House, PA.

Purpose:
The Bioanalytical Discovery and Development Sciences (BDDS) organization develops, validates, and conducts bioanalytical sample analysis across the entire J&J Innovative Medicines (JJIM) R&D portfolio from discovery through development. We are looking for an accomplished and dedicated Scientist to design and perform target engagement assays within BDDS for Johnson & Johnson portfolio projects spanning all modalities and therapeutic areas from nonclinical studies to post-market clinical development.

You will be responsible for:

• Conduct receptor occupancy method qualification and bioanalysis using multi-parameter flow cytometry of samples supporting preclinical and clinical studies to assess target engagement of therapeutics in J&J developmental pipeline.
• Work in a regulated GLP/GCLP environment under limited supervision with a high level of autonomy, encouraging a collaborative and inclusive environment.
• Promote assigned project activities through hands-on data generation, quality control (QC) and data analysis.
• Use advanced computer software packages to collect, analyze, and interpret flow cytometry data.
• Set priorities for experimental work to ensure adequate progress of team projects and objectives. Ensure laboratory efficiency as well as compliance with good laboratory practices and other regulatory guidelines.
• Author assay checklists, work instructions, standard operating procedures (SOPs), and technical reports,
• Mentor more junior colleagues in techniques, processes, and responsibilities.
• Actively participate in internal seminars and keep up-to-date with documentation, published literature and regulatory guidance’s to develop knowledge of current academic and industry practices and apply to internal Johnson & Johnson projects and processes.
• Understand and apply Johnson & Johnson’s Credo and Leadership Imperatives in day-to-day interactions with team.
• May also conduct method development for target engagement assays on other platforms including soluble target ligand binding assays and/or hybrid LC-MS/MS assays.

Qualifications / Requirements:

Education:

• Minimum of a Bachelor’s degree in Life Sciences, Biology, Immunology or a related discipline is required
• Advanced degree is preferred

Required:

• Minimum 2-4 years of experience in the pharmaceutical industry and/or academic setting
• Demonstrated experience using multi-parametric flow cytometry (6+ colors) and flow analysis software (such as Flowjo or FCS Express)
• Solid understanding of cellular techniques, including mammalian cell culture, handling and processing of human and animal (non-human primates (NHP), mice, rats, dogs, etc.) blood, PBMCs and aseptic techniques
• Familiarity with BSL2 safety practices for working in the laboratory
• Must have excellent verbal and written communication skills
• Must have strong interpersonal, organizational and documentation skills
• Must have strong motivation to quickly learn new skills, grow as a scientist and adapt to challenges of the job
• The ability to multi-task, prioritize and plan based on project needs, and work in a fast-paced dynamic environment
• The ability to independently perform experimental design, including generation, analysis and QC of data and interpretation of results
• The ability to interact and collaborate effectively in a cross-functional team environment

Preferred:

• Hands-on experience and solid understanding of GLP/GCLP bioanalysis and regulatory guidelines to assess safety and efficacy of therapeutics
• Knowledge of T cell and B cell biology and immunological mechanisms of disease and biotherapeutics
• Experience with pharmacokinetic, immune response and/or soluble target engagement assays on ELISA, MSD, LC-MS and/or similar assay platforms

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers, internal employees contact AskGS to be directed to your accommodation resource.

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