At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biological Research

Job Category:

Scientific/Technology

All Job Posting Locations:

San Diego, California, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

About Immunology

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Our Immunology team leads in the development of transformational medicines for immunological disorders and illnesses. You can influence where medicine is going by restoring health to millions of people living with immune diseases.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

We are searching for the best talent for a Senior Scientist to be in San Diego, CA.

The successful individual will provide bench support for discovery projects testing novel interventions/compounds in complex in vivo models of inflammation and in vitro systems, generating preclinical pharmacology, biomarker, and human translational data to support regulatory filings for new molecular entities, and collaborate with cutting edge academic labs and biotech companies. This individual will also participate in efforts to identify new targets for therapeutic intervention for inflammatory indications impacting skin, gut, joint, and lung.

Key Responsibilities:

• Design, perform, and interpret in vitro experiments to support target validation, mechanism of action studies, and progression of drug discovery programs.
  • Design and conduct in vivo and ex vivo pharmacology experiments with a high degree of autonomy to understand drug exposure/activity relationship.
  • Develop, troubleshoot, and validate new in vivo models (acute or chronic) and lead/instruct other team members regarding processes, techniques, or tasks.
  • Employ in silico approaches to interrogate multi-omic datasets to identify key molecular features and cellular mechanisms and pathways contributing to disease pathogenesis in tissues of interest (e.g. skin, gut, joint, lung).
• Document research in internal discovery reports, manuscripts for external publication, and other formats as required.
• Present research at internal meetings and external scientific forums.
• Work closely with colleagues from partner organizations to enable and/or support research activities.
• Work with leadership to establish and maintain involvement in any external collaborations required to support research goals.

Requirements:

• PhD in Immunology/Pharmacology/Cell Biology or related discipline with 1-3 years additional lab experience.
• Experience with in vitro cell culture (e.g. adherent cells and immune cells) is required.
• Experience with in vivo techniques (e.g.. rodent handling, IP/SC/PO dosing, tissue harvesting, inflammatory models) is required.
• Experience with standard methods for assessment of gene and protein expression, including quantitative PCR, ELISA- and flow cytometry-based methods, is required.
• Experience with bioinformatics tools for analysis of differential gene expression in RNAseq datasets is preferred.
• Strong oral, written, and fit-for-purpose communication skills are required.
• Excellent interpersonal and collaborative skills with an ability to operate as part of a team in highly interdependent environment are required.

The anticipated base pay range for this position is $105,000 to $166,750

Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.

Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).

This position is eligible to participate in the Company’s long-term incentive program.

Employees are eligible for the following time off benefits:

– Vacation – up to 120 hours per calendar year

– Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington – up to 56 hours per calendar year

– Holiday pay, including Floating Holidays – up to 13 days per calendar year

– Work, Personal and Family Time - up to 40 hours per calendar year

Additional information can be found through the link below. For additional general information on company benefits, please go to: - https://www.careers.jnj.com/employee-benefits

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource.

The anticipated base pay range for this position is:

Additional Description for Pay Transparency:

Push the boundaries of science to transform health—and your career.

Join us and advance life-changing treatments for people who need them most. At Johnson & Johnson, our focus is on improving global health equity and developing MedTech and pharmaceutical innovations that impact the future of health. Using AI and robotics to transform surgery or helping data scientists and clinicians formulate new ways to diagnose and treat disease, this work may sound like sci-fi, but it’s all science, all real, and could be your career. Whatever your background, skills, or career goals, there’s a place for you to help solve some of the world’s most pressing health challenges with us.

Accelerate your career while changing the world.

Each of our broadly-based family of companies offers an inclusive and empowering culture and employee benefits (like paid time off to volunteer, transgender-inclusive and same-sex partner health insurance coverage, and more) designed to help you live your best life, however you define it. And our best-in-class learning and development approaches, mentorship, and access to innovators across the world will help you grow your skills and reach your career goals. Because when you're at your best, nothing stands between you and your next breakthrough.