Job Description

ALS is a neuromuscular disorder characterized by the degeneration of motor neurons, leading to paralysis and ultimately death. A common phenotype found in motor neurons of ALS patients is the mislocalization and accumulation of large protein aggregates. Understanding the mechanisms that drive this aggregation and how it contributes to neurodegeneration is critical to the development of novel therapies for ALS. A successful candidate for this position will develop high-fidelity in vitro models of this phenotype using iPSC-derived cells, state-of-the-art high-content microscopy and image-based analyses. Further, he/she will utilize these models for target validation and mechanism of action studies to identify novel therapeutic hypotheses, ultimately leading to publication of their work in a high-impact journal.

The selected individual is expected to independently plan/execute experiments, rigorously analyze and interpret the results to achieve agreed upon objectives. The candidate will be expected to build technical expertise in reagent and assay development and be comfortable working in a group setting. The incumbent will contribute to development of new lines of drug discovery research or new technologies in pursuit of project objectives.

Qualifications

• The successful candidate must possess a strong drive for discovery and aim at publishing in high-impact journals. A significant understanding of basic neurobiology of neurodegenerative diseases as well as some background in ALS biology is desirable.
• Strong communication skills and the ability to work effectively in a highly collaborative research environment is essential.
• The successful candidate should have a proven track record of independent research as demonstrated by peer-reviewed publications.
• Experience in the development of cell-based assays using various assay formats for small molecule or LOF-based phenotypic screening is desirable.
• ·       Solid understanding of microscopy, image based analysis and experience with cell/tissue culture procedures. Experience with iPSC-derived neurons or primary neuronal cultures is desirable.
• Experience with techniques commonly used in molecular and cellular biology, for example: qPCR, RNA-seq, transfection/transduction, immunoprecipitation and immunoblotting.
• Strong problem-solving and troubleshooting skills, as well ability to work independently are essential.
• Excellent organization, oral and written communication skills.

EDUCATION:

Requires a Ph.D. in the areas of Neurobiology, Cell Biology or similar relevant field.

Additional Information

This Postdoctoral Scientist position is for a fixed duration of three years (and extendable by an additional year). Applications will be accepted until the position is filled. Funding is available for the selected applicant to start immediately. When electronically applying for this position, please include (in one PDF document) a cover letter, curriculum vitae, publication list and a brief description of research interests.