Job Description

_This application is for a 6-month student role from July - December 2022. Resume review begins in January 2022. _

Work within one of several departments in Biogen’s Product and Technology Development (PTD) organization engaged in laboratory activities supporting the development and characterization of therapeutic products, manufacturing processes or new technologies.   

POSITION DESCRIPTION  

The Co-op position provides an exciting opportunity to gain hands-on experience and exposure to the manufacturing process R&D activities. Working closely with the Antisense Oligonucleotide (ASO) chemistry and analytical development teams. 

Sulfurization is a critical step in antisense oligonucleotides synthesis; however, the mechanism is poorly understood. We are now investigating alternative sulfurization reagent/system to minimize impurity formation and to increase the purity of drug substance. The goal of this project is to investigate the efficiency of different sulfurization reagent, design solid and solution phase experiment, verify the critical results, conduct intermediates characterizations, and mechanistic study to improve the current sulfurization process and/or design better sulfurization agents based on the knowledge gained. 

• Execute, document, and communicate results from sulfurization experiments  
• Actively interacts with group scientists to gain understanding of principles, experimental designs, and data interpretation.  
• Complete a research report before the completion of the Co-op term.

Qualifications

• Basic organic chemistry knowledge and lab skills: chromatography, balance, HPLC, NMR etc. 
• Hands-on experience working in an Organic chemistry laboratory

To participate in the Biogen Internship Program, students must meet the following eligibility criteria: 

• Legal authorization to work in the U.S. 
• At least 18 years of age prior to the scheduled start date 
• Be currently enrolled in an accredited college or university

EDUCATION

Master’s or Doctoral students majoring in Organic Chemistry. 

Additional Information

All your information will be kept confidential according to EEO guidelines.