Job Description

ABOUT THIS ROLE  

As a Senior Associate Scientist in Biogen's DMPK department you will be expected to conduct PK studies in nonclinical animal species of various modalities including small molecule compounds, monoclonal antibodies, and gene therapy medicinal products (GTMP) to meet potentially challenging needs of projects. You will have experience on developing novel in vivo and ex vivo animal models to solve challenge ADME issues of drug candidates.

WHAT YOU’LL DO  

• You will conduct PK studies in nonclinical animal species of various modalities including small molecule compounds, monoclonal antibodies, and gene therapy medicinal products (GTMP) to meet potentially challenging needs of projects.
• You will dose mice and rats via the routes including but not limited to IV, PO, SC, IP, IT, and ICV.   
• You will collect rodent samples including but not limited to plasma, serum, urine, cerebrospinal fluid (CSF), brain, spinal cord, and other tissues.
• You will interface with bioanalytical scientists or outsourcing study managers to deliver and/or ship the rodent samples to CRO in a timely manner.
•  You will interface with Biogen institutional animal care and use committee (IACUC) to write and update experimental protocols.

WHO YOU ARE 

You are experienced at developing novel in vivo and ex vivo animal models to solve challenging ADME issues of drug candidates.  The ability to perform ligand-binding assays for large molecule quantifications is a plus

Qualifications

REQUIRED SKILLS

• Bachelor’s Degree in Biology, Biochemistry, Analytical Chemistry, Pharmaceutical Sciences, or a related field,  with at least 4-6 years of experience, or a Master’s Degree with at least 2-4 years of related industry experience.
• Extensive knowledge and hands-on experience in conducting rodent PK studies on a regular basis.
• Hands-on experience with dosing mice and rats via the routes including but not limited to IV, PO, SC, IP, IT, and ICV.
• Hands-on experience with rodent sample collection including but not limited to plasma, serum, urine, CSF, brain, spinal cord, and other tissues.

PREFERRED SKILLS 

• Preferred experience with non-conventional in vivo PK studies such as studies with bile duct cannulated rats or with portal vein cannulated rats.
• Hands-on experience in quantification of biologics (e.g. mAb) by ligand-binding assay or LC-MS is a plus.
• Experience in studying CNS drug disposition and blood-brain barrier is a plus.

*LI-RD8

Additional Information

Biogen’s DMPK department is seeking a highly motivated Sr. Associate Scientist with excellent knowledge and hands-on experience in conducting animal pharmacokinetic (PK) studies to enable discovery and development of innovative therapeutics for people living with serious neurological and neurodegenerative diseases