Job Description

Biogen is seeking a highly motivated, results driven Senior Associate Scientist to join the Drug Metabolism and Pharmacokinetics (DMPK) department at our Kendall Square site in Cambridge, Massachusetts. In this role, the candidate will add scientific expertise to the discovery and non-clinical development of small molecule therapeutics by carrying out critical path in vitro ADME assays. He/she will be primarily responsible for conducting, optimizing, and troubleshooting ADME screening assays, in particular transwell permeability (MDR1/MDCK and BCRP), to evaluate new chemical entities across the discovery project portfolio. He/she will directly impact the direction of active therapeutic projects and contribute to building in silico predictive models to improve our compound design. 

The core responsibilities of this position are to:

• Maintain cell cultures for mammalian cell-based assays
• Conduct high throughput ADME screening assays using Tecan and Hamilton automated liquid handlers and state-of-the-art HT LC/MS analytical systems
• Conduct, analyze, interpret, and document (in electronic notebook) ADME studies and communicate ADME screening study results to internal stakeholders

In addition to the core responsibilities, the role may allow additional opportunities such as CRO interactions, contribution to scientific reports, evaluation of emerging in vitro and in silico tools, contribution to the implementation of new assays/techniques, authorship of scientific papers and presentations at scientific meetings where appropriate. You will join a fast paced, collaborative, and strong scientific community at Biogen deeply committed to scientific excellence in developing life-changing therapies for unmet medical needs.

Qualifications

Bachelor’s degree and 2-6 years of scientific experience in ADME

Accomplished in the use of Microsoft Excel, Word, and PowerPoint

Experience in cell culture handling

Experience with mass-spectrometry based analysis (high throughput LC/MS)

Effective oral and written communication skills are essential

Utilizing applications to upload data to LIMS systems

PREFERRED QUALIFICATIONS INCLUDE:

Experience with transwell permeability assays

Experience with TECAN and Hamilton automation

Previous skills working with High Throughput front-ends such as the RapidFire, ADDA, or multiplexing

Familiarity with programming in Excel/VB or Pipeline Pilot

Critical and proactive thinking and experience in drug discovery and/or development; expertise with implementing, optimizing and troubleshooting in vitro transporter assays; and demonstrated ability to communicate with team members across broad disciplines

Additional Information

All your information will be kept confidential according to EEO guidelines.