Postdoctoral Research Fellow Discovery Neuroscience, Movement Disorders and Translational Date:Jan 4, 2019 Location:West Point, PA, US -Requisition ID:POS000275 Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified itslegacy for over a century. Mercks success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare. Merck is on a quest for cures and is committed to being the worlds premier, most research-intensive biopharmaceutical company. Today, were doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Mercks leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. Be a part of the legacy: MRL Postdoctoral Research Fellow Program: The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery. The Neuroscience Department is seeking postdoctoral fellowship applicants to be a part of an interdisciplinary team of biologists, geneticists, and chemists within Merck Research Laboratories. Projects will seek to develop cell biology models and further understand cellular mechanisms pertinent to neurodegenerative disease, especially interrogating the mechanisms of synucleinopathy in Parkinsons disease. Postdoctoral fellows will have the opportunity to leverage genomic and transcriptomic findings to drive in vitro and in vivo studies to identify and validate cellular pathways relating to disease state using cell-based and rodent models. Candidates should have a strong background in neuroscience and in vitro techniques, a familiarity with application of bioinformatics to discovery research and a passion for interrogating the cellular mechanisms responsible for neurodegenerative disease. This fellowship is a unique opportunity to learn about the process of drug discovery while contributing to the advancement Merck's drug development pipeline. Responsibilities include but are not limited to: -Working with disease area collaborators in the planning and execution of studies. -Conducting in vitro cell culture experiments and analysis using a variety of techniques including but not limited to protein quantification and visualization, mRNA profiling, e.g. single cell RNAseq, and genetic manipulation via siRNA or viral transduction. -Independent analysis and interpretation of data. -Communication of findings at project teams and external conferences as well as through peer-reviewed publications.mrlpostdoc Qualifications Education Minimum Requirement: -A PhD with less than (3) years of postdoctoral experience OR graduating with a PhD by summer of 2019. Required Experience and Skills: -Ability to conceive, design, execute and communicate complex experiments in the field of neuroscience as evidenced by publications. -Background in neuroscience, neurodegenerative disease or related discipline. -Fluency in primary and recombinant cell culture and performing genetic manipulations.in cell models. -Fluency in in vitro lab techniques including protein and mRNA extraction, measurement, & visualization. -Must be an independent scientist with an ability to excel in a team environment.Preferred Experience and Skills: -Bioinformatics/genomic analysis and single cell RNAseq techniques. -Models of protein aggregation, misfolding, and/or lysosomal/mitochondrial dysfunction. -Rodent handling and rodent models of neurodegenerative disease. Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and were counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, were inventing for life. If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to -. Search Firm Representatives Please Read Carefully: Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means. Visa sponsorship is not available for this position. For more information about personal rights under Equal Employment Opportunity, visit: -Merck is an equal opportunity employer, Minority/Female/Disability/Veteran proudly embracing diversity in all of its manifestations. Job:Post-Doctoral Fellow Other Locations: Employee Status:Regular Travel:No Number of Openings:1 Shift (if applicable):N/A Hazardous Materials: Company Trade Name:Merck Nearest Major Market:Philadelphia