Postdoctoral Research Fellow Peptide Metabolism & Permeability Date:Jan 3, 2019 Location:Kenilworth, NJ, US -Requisition ID:POS000294 Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified itslegacy for over a century. Mercks success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare. Merck is on a quest for cures and is committed to being the worlds premier, most research-intensive biopharmaceutical company. Today, were doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Mercks leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. Be a part of the legacy: MRL Postdoctoral Research Fellow Program. The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery. As a postdoctoral fellow in Merck Research Labs Pharmacokinetics, Pharmacodynamics, and Drug Metabolism ADME group based in Kenilworth, NJ, you will work with a highly collaborative team of scientists in a state-of-the-art laboratory to design and develop in vitro models to study the intracellular exposure of therapeutic peptide analogs (macrocycles, linear peptides and CPPs). This work will enable understanding of the role of metabolism as a limiting factor for intracellular exposure of cell permeable peptides. Responsibilities include but are not limited to: -Conducting in vitro metabolism and cell permeability experiments with peptides using various subcellular fractions and cell-based assays. -Peptide metabolite analysis. -Collaborating with Merck scientists to develop models to analyze intracellular exposure of peptides as a function of metabolism and permeability. -Data interpretation, manuscript preparation and publication, and presentation of results at internal and external meetings. -Contribute to a safe and compliant laboratory work environment.mrlpostdoc Qualifications Education Minimum Requirement: -A PhD with less than (3) years of postdoctoral experience OR graduating with a PhD by summer of 2019.Required Experience and Skills: -Ability to conduct in vitro assays using cell-free and cell culture systems. -Strong knowledge and expertise in cell biology experimentation. -Prior experience with cell permeable peptides. -A strong publication track record. -Must be an independent and self-motivated scientist.Preferred Experience and Skills: -Expertise or an interest in learning peptide analysis by LC-MS/MS and/or HRMS techniques. -Experience in studying peptide metabolism in vitro and in vivo, and the enzymes involved. -Understanding of peptide chemistry. Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and were counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, were inventing for life. If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to -. Search Firm Representatives Please Read Carefully: Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means. Visa sponsorship is not available for this position. For more information about personal rights under Equal Employment Opportunity, visit: -Merck is an equal opportunity employer, Minority/Female/Disability/Veteran proudly embracing diversity in all of its manifestations. Job:Post-Doctoral Fellow Other Locations: Employee Status:Regular Travel:No Number of Openings:1 Shift (if applicable):N/A Hazardous Materials: Company Trade Name:Merck Nearest Major Market:New York City Nearest Secondary Market:Newark