Postdoctoral Research Fellow Oncology Ultrasonic Drug Delivery Date:Jan 3, 2019 Location:Rahway, NJ, US -Requisition ID:POS000282 Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified itslegacy for over a century. Mercks success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare. Merck is on a quest for cures and is committed to being the worlds premier, most research-intensive biopharmaceutical company. Today, were doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Mercks leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. Be a part of the legacy: MRL Postdoctoral Research Fellow Program The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery. As a postdoctoral fellow in Merck Research Labs Sterile Formulation Sciences based in Kenilworth, NJ, you will work with a highly collaborative team of scientists and engineers to design, develop and validate techniques to ultrasonically assist the delivery of small and large molecule therapeutics with a target for hard to treat tumors. The objective of this project will be to develop and characterize sonoporation stimulation techniques in order to improve the distribution and absorption of our co-formulation/ co-administrations for molecules targeting various biological mechanisms with specific focus on (1) enabling enhanced dense tumor penetration, (2) addressing visceral tumor metastasis in concert with systemic administration, and (3) treating surgically non-resectable tumors. Responsibilities include but are not limited to: -Literature and technical review of sonoporation techniques for application to oncology. -Application of ultrasound and investigation of cavitation efficacy and impact to cells and tissue. -Formulation approaches and large molecule characterization for ultrasound drug delivery. -Biological evaluation on the impact of ultrasound as it applies to co-formulation/ co-administrations of molecules targeting various biological mechanisms Collaborating with Merck and external scientists conducting in vivo cancer model studies to correlate and validate the in vitro models. -Data interpretation, manuscript preparation, publication and presentation of results. -Contribute to a safe and compliant laboratory work environment. mrlpostdoc Qualifications Education Minimum Requirement: -A PhD with less than (3) years of postdoctoral experience OR graduating with a PhD by summer of 2019. Required Experience and Skills: -Experience with sonoporation/ultrasound. -Biophysical characterization of large molecules. -Diffusion cell apparatus setup and characterization techniques (e.g. Franz).Preferred Experience and Skills: -Fluid mechanics / dynamics of cavitation. -Tumor staining and characterization. -Experience studying cancer-associated fibroblasts. -Experience with three dimensional tissue culture models. Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and were counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, were inventing for life. If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to -. Search Firm Representatives Please Read Carefully: Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means. Visa sponsorship is not available for this position. For more information about personal rights under Equal Employment Opportunity, visit: -Merck is an equal opportunity employer, Minority/Female/Disability/Veteran proudly embracing diversity in all of its manifestations. Job:Post-Doctoral Fellow Other Locations: Employee Status:Regular Travel:No Number of Openings:1 Shift (if applicable): Hazardous Materials: Company Trade Name:Merck Nearest Major Market:New York City Nearest Secondary Market:Newark