Research Scientist Structural Biology & Biophysics (BOS) Boston, MA Full-Time Job Description Vertex is seeking a highly motivated and inventive scientist with a passion to apply biophysical techniques to drug discovery. We are looking for someone with a proven track record in biochemical and biophysical research including protein purification and expression, development of functional assays and structural studies. You will work within a team of biochemists, biophysicists and structural biologists, with these teams you will design and execute elaborate experiments for major research projects. Key Responsibilities: - Expression and purification of challenging biochemical drug targets - Designs and performs advanced, complex biochemical and biophysical experiments - Independently analyzes data to distill conclusions and set new experimental directions - Troubleshoots and optimizes experiments - Innovates on research methodology to a high degree, in order to address more important questions - Demonstrates resourcefulness in running multiple activities concurrently, all related to achievement of goals/objectives - Adapts to new projects rapidly and to multiple projects effectively - Is up to date with the scientific literature in the field and beyond - Actively participates in discussions in biochemistry team meetings - Presents results to biochemistry and project teams#LI-BS1 Minimum Qualifications - PhD in Structural Biology, Biochemistry, Biophysics or relevant field with 2-5 years post-degree experience - Experience in protein expression from multiple organisms (mammalian, insect, bacterial, etc.) - Track record of protein purification of targets including membrane proteins - Previous use of manual and automated chromatography systems - Use of biochemical techniques (e.g. Western blot, SDS-PAGE, etc.) - Familiarity with biophysical techniques to assess interactions among proteins, nucleic acids and small-molecule ligands an asset (e.g. SPR, MST, ITC, etc.) - Track record of productivity as evidenced by a strong publication record - Ability to communicate effectively with his/her supervisor - Self-motivation, organization, effective communication and presentation skills - Ability to navigate a dynamic work environment - A dream to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society Company Information Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. Founded in 1989 in Cambridge, Massachusetts, our corporate headquarters is now located in Boston's Innovation District, and our international headquarters is in London, United Kingdom. We currently employ approximately 2,500 people in the United States, Europe, Canada, Australia and Latin America with nearly two-thirds of our staff dedicated to research and development. Vertex is consistently recognized as one of the industrys top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. Our research and medicines have also received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the French Prix Galien and the British Pharmacological Society awards. For additional information and the latest updates from the Company, please visit www.vrtx.com. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com. Req ID 11253BR