ABOUT ABBVIE

AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health, and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio.

For more information about AbbVie, please visit us at www.abbvie.com.

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ADENO-ASSOCIATED VIRUS PREFORMULATION INTERNSHIP OVERVIEW

Envision spending your summer working with energetic colleagues and inspirational leaders, all while gaining world-class experience in one of the most dynamic organizations in the pharmaceutical industry. This is a reality for AbbVie’s Experiential Interns.

Recombinant adeno-associated virus (AAV) vector has been the most popular vector choice for in vivo gene therapy, due to its long-term expression and lack of pathogenicity in humans. Hundreds of ongoing clinical trials, utilizing different AAV serotypes, target multiple genetic diseases such as cystic fibrosis and hemophilia and eye diseases such as age-related macular degeneration (AMD). At AbbVie, rAAV is a growing therapeutic modality, requiring an increase of in-house development knowledge. However, the developability assessment and preformulation development of AAV are challenging due to limited material availability and AAV structure complexity. Both the capsid and its packaged DNA cargo are potential sources of AAV instability. There is an urgent need for detailed characterization of the physicochemical stability of AAVs to enable rapid screening and early drug product development.

KEY RESPONSIBILITIES INCLUDE:

• Develop stability-indicating AAV characterization methods that are suitable for the small amounts of materials typically available at late-discovery/early-development stages

• Develop a representative platform formulation for physical and chemical stability evaluation of AAV candidates under stressed conditions and in-use condition

MINIMUM QUALIFICATIONS

• Currently enrolled in university, pursuing a Bachelor’s, Master’s, or PhD in Biology, Chemistry, Biophysics, Biochemistry, Biopharmaceutics, Pharmaceutical Sciences, Chemical Engineering or related field

• Must be enrolled in university during the internship period

PREFERRED QUALIFICATIONS

• Currently enrolled in PhD program

• Exposure to protein biophysics

• Laboratory experience in protein formulation

BENEFITS AND AMENITIES

• Competitive pay

• Travel, transportation and lodging support for eligible students

EQUAL EMPLOYMENT OPPORTUNITY

At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.

AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio.