About AbbVie

AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health, and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio.

For more information about AbbVie, please visit us at www.abbvie.com.

Follow @abbvie on Twitter, Facebook, Instagram, YouTube, and LinkedIn.

2024 QTAS In Vitro Intern Overview

Envision spending your summer working with energetic colleagues and inspirational leaders, all while gaining world-class experience in one of the most dynamic organizations in the pharmaceutical industry. This is a reality for AbbVie Interns.

The QTAS group supports Discovery and Development Projects by generating in vitro ADME data, pharmacokinetics characterization, prediction of human efficacious dose/pk and drug-drug interactions (DDI) and in vitro to in vivo extrapolations for clinical candidates. QTAS works closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings. We are looking for a highly motivated student research intern to participate in our internship program. In this role, the intern will gain hands-on experience in the design and conduct of experimental research projects, data analysis, presentation of key scientific findings as well as experience the rich culture of our organization. The selected candidate will gain insight into research approaches related to early drug disposition estimation and support to first-in-human study design. The internship will focus on in-house validation of uptake transporter assay for screening compounds in Discovery.

Key responsibilities include:

• Mammalian cell culture (primary and recombinant).

• Uptake transporter studies (substrate, inhibition, kinetics).

• Hepatocyte uptake studies.

• LC-MS/MS-analysis.

• Estimating tissue clearance, predicting drug-drug interactions potential.

• PBPK modeling and simulations to predict tissue drug exposure and PK-DDI.

Minimum Qualifications

• Currently enrolled in university, pursuing a [Master’s/ PhD/ PharmD] degree in Pharmaceutical Sciences, Pharmacology, Chemistry, Biochemistry, or related field.

• Completed at least 2+ years of graduate level studies prior to start of internship.

• Returning to university for at least 1 semester/quarter post-internship.

Preferred qualifications

• Prior experience with in vitro or in vivo membrane transporter studies (pharmacokinetics/disposition) is a plus.

• Knowledge in ADME/DMPK role in drug development.

• Experience in drug-drug interactions (enzyme/transporters) is a plus.

• Hands-on experience with PBPK modeling (Simcyp/GastroPlus) is a plus.

• Working experience with mammalian cells, enzyme kinetics (non-linear data fitting).

• Data analysis/statistics experience.

• Expected graduation date between December 2024 - July 2025.

Additional Requirements

• Strong self-motivation, organized, and ability to work with other team members, towards a common goal.

• Excellent oral and written communication skills.

Benefits and Amenities

• Competitive pay.

• Relocation support for eligible students.

• Opportunity to connect with AbbVie leaders and scientists.

Equal Employment Opportunity at AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.

AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio.