Co-op, Discovery Pharmacology (Jan - June 2022)
At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
CURRENT SIX-MONTH CO-OP OPPORTUNITY
Discovery Pharmacology and In Vivo Biology (Cambridge, MA)
GOAL: Development and characterization of key tools and assays to support in vivo Oncology target ID and drug discovery.
We are seeking a co-op to join the Discovery Pharmacology and In Vivo Biology team at our new state-of-the-art facility in Cambridge, MA. Our group is charged with leveraging preclinical mouse models to enable the discovery of new biology and therapeutics for the treatment of cancer. This project will focus on developing and executing CRISPR-based in vivo discovery of tumor cell intrinsic mechanisms that control cancer fitness, as well as developing and characterizing key tools for in vivo utilization to support cancer drug discovery.
The candidate will gain experience in a variety of in vitro and ex vivo skills including but not limited to cell culture, transfection/transduction, tumor dissociation, DNA/RNA/protein extraction, CRISPR/Cas9-mediated genome editing, western blotting, flow cytometry.. The candidate will not perform any in vivo experiments..
To achieve the above goals, this project will involve the following assignments:
WORK/PLAN WITH MANAGER TO IDENTIFY RELEVANT TOOLS AND TUMOR MODELS FOR DEVELOPMENT (10%)
DEVELOP, OPTIMIZE AND EXECUTE PROTOCOLS TO DERIVE AND CHARACTERIZE GENETICALLY-ENGINEERED CANCER CELL LINE MODELS, PERFORM GENETIC SCREENS, AND DEVELOP/OPTIMIZE NOVEL CELLULAR ASSAYS (80%)
EDUCATION AND TRAINING: 10%
REQUIREMENTS/EDUCATION:
Desired background and skills include:
KEY LEARNINGS:
Become familiar with in vitro and ex vivo techniques including:
Gain an understanding of the importance of basic biology in drug discovery and development in BioPharma.
KEY DELIVERABLES AT PROJECT COMPLETION:
At end of the co-op assignment, the student will be required to present a summary of their project and key learnings
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Bristol Myers Squibb is a leading global biopharma company focused on discovering, developing and delivering innovative medicines for patients with serious diseases in areas including oncology, hematology, immunology, cardiovascular, fibrosis and neuroscience. Our employees work every day to transform patients’ lives through science.