At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Position Summary

Bristol Myers Squibb is a world-leader in targeted protein degradation therapeutics. We are seeking a post-doctoral fellow to join our growing group within Oncology Discovery that blends cell biology and proteomics to study novel degrader compounds and their effects on biological pathways.

The primary project seeks to understand the mechanism of action of a newly developed kinase degrader upon cellular and oncogenic pathways. The fellow will collaborate with the proteomics team to identify pathways affected by our degrader compounds and will be responsible for using cell biology approaches to understand the underlying biology. The project is untethered from pipeline products and can be freely published.

The ideal candidate will have a strong background in experimental cell and molecular biology including CRISPR knockout and mutagenesis, lentiviral expression, and biochemical techniques. Familiarity with large datasets such as those from DNA sequencing and proteomics is also desired.

This fellowship boasts a highly competitive salary, extensive resourcing, and is an exciting opportunity for a candidate to gain first-hand experience in targeted protein degradation, one of the hottest and most exciting areas in drug development.

Key Responsibilities

• Lead projects using cell biology to study protein degrader small molecules

• Design and perform loss-of-function and gain-of-function cell biology experiments

• Collaborate with proteomics specialists to generate and analyze proteomics data

• Collaborate with in vivo pharmacologists

• Collaborate with other post-doctoral fellows on inter-disciplinary projects

• Publish work in scientific journals

• Present work at internal and external scientific conferences

Qualifications & Experience

• Ph.D in biology or related field with experience in cell biology

• In-depth knowledge of cell cycle and oncology pathways

• Strong publication track-record

• Required technical expertise:

  • Cell culture, plate-based assays, CRISPR, RNAi, and cloning.

  • Lentivirus, qPCR, western blotting,

  • Windows, MS Office, graphing software (eg PRISM) or familiarity with R or python

• Desired expertise, but not required:

  • Experience with phospho-proteomics protocols and/or data analysis

  • Experience with cell cycle assays (FACS) and immunofluorescence microscopy

  • Experience with ubiquitin or protein degradation technologies

  • Experience with kinase biology and phosphorylation

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Bristol Myers Squibb is a leading global biopharma company focused on discovering, developing and delivering innovative medicines for patients with serious diseases in areas including oncology, hematology, immunology, cardiovascular, fibrosis and neuroscience. Our employees work every day to transform patients’ lives through science.