The Medicine Design group in Cambridge, MA is seeking a highly driven and innovative Ph.D.-level scientist to join our chemical biology group as a Postdoctoral Research Fellow in driving therapeutic innovation through technology development. This is a unique opportunity to be trained in the field of chemoproteomics, work collaboratively with diverse research teams within Pfizer, and publish in high-impact journals. By the end of the program, the postdoc will be proficient in designing chemical probes, photo-crosslinking++,++ target engagement methodologies, mass spectrometry sample prep/data analysis and will be fully prepared to contribute to early-stage target engagement and target deconvolution studies. The ideal candidate should have strong background in organic chemistry, biochemistry, or chemical biology, and have a good understanding of biology and statistics.

ROLE RESPONSIBILITIES

• Demonstrate strong technical and scientific rigor in project planning.
• Proactively conduct literature searches to gather relevant information to form hypotheses for testing experimentally.
• Design chemical probes and develop a novel target engagement methodology for studying compound interactions in a whole cell environment.
• Desire to learn and help maintain nanoLC/mass spectrometers for conducting chemoproteomic experiments.
• Generate and effectively communicate results regularly at internal meetings, make data-driven decisions to shape the direction of research project.

QUALIFICATIONS​

Basic Qualifications

• Ph.D. in Chemistry, Biochemistry, Chemical Biology, or a related discipline is required
• Ability and desire to work in a fast-paced, interdisciplinary scientific team 
• Strong problem-solving and analytical skills.
• Excellent written and oral communication skills.
• Proficient with data reporting and analysis software, as well as strong organizational skills.

Preferred Qualifications

• Experience with photochemical crosslinking of compounds to proteins 
• Mammalian cell culture experience and affinity enrichment from live cells.
• Familiarity with QExactive HF and/or Orbitrap Lumos Mass Spectrometers is desired but not required.

PHYSICAL/MENTAL REQUIREMENTS

This position is a lab based position so candidate must be comfortable lifting, standing, sitting, walking, bending, ability to perform mathematical calculations, and ability to perform complex data analysis.

OTHER JOB DETAILS

Eligible for Relocation Package

Eligible for Employee Referral Bonus

Must have Work Authorization in the United States

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment.  As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.

Pfizer Inc. is a research-based, global biopharmaceutical company. We apply science and our global resources to bring therapies to people that extend and significantly improve their lives through the discovery, development and manufacture of medicines, vaccines, medical devices and consumer healthcare products.