Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Job Description

AbbVie is expanding in the West Coast, with AbbVie Bay Area (ABA) in South San Francisco focused on the discovery and development of novel immune-oncology therapeutics. About 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work at ABA. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at AbbVie in the South San Francisco site.

We are seeking a Scientist I to join a talented and collaborative team to develop cell culture processes for pre-clinical and clinical manufacture. In this position, the candidate will perform cell culture process development, scale-up, and technology transfer activities in a well-supported and dynamic environment to help advance novel therapeutics into pre-clinical and clinical studies.

Responsibilities:

• Develop cell culture processes for INDa-enabling toxicology studies and Phase I GMP manufacture
• Use scientific and engineering principles to scale up cell culture processes from ambr250 and/or 2L benchtop scale up to the 4000L scale
• Use scientific and engineering principles to scale up primary recovery (harvest) processes
• Collaborate closely with project leads from the Cell Line Development and Purification Development groups to meet dynamic project timelines
• Lead the tech transfer of master cell banking, cell culture, and primary recovery processes for Phase I GMP manufacture
• Author and review technical development reports, GMP campaign summary reports and relevant CMC sections for regulatory submissions
• Lead and/or support the continuous improvement of business processes in the Cell Culture group
• Develop innovative technologies and enhance our cell culture process understanding
• Present and/or publish scientific findings at internal forums, external conferences, and/or peer-reviewed journals

Qualifications

Required:

• Bachelor of Science with at least 5 years of industrial CHO cell culture experience or Master of Science with at least 2 years of industrial CHO cell culture experience
• Proficient in aseptic technique in a biosafety cabinet
• Proficient in designing and executing and scaling up cell culture processes in the Ambr® 250 and 2L bioreactors
• Proficient in designing and scaling up primary harvest processes
• Hands on experience with single use bioreactors at the 2L to 500L scale, continuous disk stack centrifugation, and depth filtration
• Have a strong working understanding of CHO metabolism, cellular transport, and cell culture and primary recovery scale-up principles
• Able to independently design, execute, and interpret laboratory experiments to answer specific scientific questions
• Have strong verbal communications skills and writing skills to clear articulate messages and scientific data to a variety of technical and non-technical audiences
• Forward-thinking and able to lead and contribute to scientific/technical discussions
• Have excellent attention to detail and the ability to keep detailed written records in an electronic lab notebook or batch record
• Proficient with Microsoft Office software (MS Excel, Word, PowerPoint, Outlook, Teams)

Preferred:

• Experience with media preparation
• Experience with media development
• Experience with transient transfection in CHO/HEK cells
• Experience with designing and analyzing Design of Experiment experiments
• Experience with late-stage process characterization and validation
• Experience with programming, i.e., VBA, Java, Python

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html

Salary: $71000 - $134500

AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio.