COMPANY OVERVIEW:

At 1859, we are creating a pico-scale HTS platform (pico-HTS) that enables us to test millions of small molecule potential medicines in a single day and at an exponentially lower cost point compared to conventional HTS. At scale, our technology has the potential to usher in the promise of precision medicine and democratize the medicine discovery process. At 1859, we are committed to scientific integrity, discipline, objectivity, and openness. Our team consists of very talented chemists, assay biologists, material scientists, integration engineers, automation specialists and informaticians working closely together to bring our screening technology to the world.

We are comprised of high-performance engines, not cogs, and we invest in our people! Benefits include: paid holidays, PTO, a variety of medical plans, dental and vision insurance, a 401(k) plan, employee recognition awards, happy hours, company activities, and equity incentives. We are committed to training and career development for our people. Our goal is to provide a collaborative, data driven, productive and highly efficient company culture.

If you have a passion for changing the world of new medicine discovery, we encourage you to apply!

POSITION SUMMARY:

In this laboratory-based position, the successful candidate will have an active role in testing sorted material by 1859’s pico-HTS platform using Next-generation sequencing (NGS). You will also participate in the preparation of DNA encoded chemical libraries to be tested on 1859’s pico-HTS platform. This includes material preparation for NGS, chemical libraries DNA encoding, post library synthesis DNA damage evaluation and development of QC assays for DNA-Encoded compound libraries. Strong people skills and the ability to thrive in a team and goal driven environment are key attributes.

This role will require close interaction with internal cross functional groups, including Chemistry, Method Development, Manufacturing, Automation and Quality Assurance. You will give technical reports and presentations, document all aspects of the project, assist in QC/QA, and ensure that all documentation is ready for internal and external audits.

KEY RESPONSIBILITIES:

• Performing preparations for next-generation sequencing (NGS) 

• Assisting in QC assays for DNA-Encoded compound libraries development

• Performing post library synthesis DNA damage evaluation

• Supporting DNA encoded libraries manufacturing

• Performing chemical libraries encoding 

• Updating LIMS as necessary with sample processing

• Creating documentation as requested by Quality Department

• Assisting with maintaining a safe working environment and operating in a safe manner

REQUIREMENTS:

• Bachelor’s degree or higher education; preferably in Molecular Biology 

• 3+ years of experience in a biotechnology or pharmaceutical company

• 3+ years of relevant working experience in R&D or Product Development 

• Proven technical proficiency and demonstrated skill in executing, and interpreting molecular biology experiments

• Technical expertise in DNA extraction, nucleic acid amplification techniques (qPCR, end point PCR) and sample preparation for NGS 

• Experienced in troubleshooting NGS experiments

• Ability to use or learn automation equipment and develop assays in 96 or 384-well formats

• Experienced in the creation of documents to describe processes and procedures for Manufacturing or Product Development

• Must be able to work both independently and collaboratively within highly interdisciplinary teams

• Working knowledge and experience with data analysis software, such as JMP or GraphPad 

• Outstanding written and oral communication skills

• Strong interpersonal skills capable of working with a diverse group of people

• Self-motivated, results oriented team player who leads by example, enthusiastically perseveres until ambitious goals are achieved, and reacts to situations quickly and decisively

HIGHLY DESIRABLE:

• Experience with running and interpreting HPLC, MS and LC-MS data

• Experience in IVD assay development

• Experience in QC assays development and definition of acceptance criteria based on quantitative metrics

• Experience with robotic liquid handling like Tecan

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We take pride in fostering an environment where all team members are afforded the freedom to pursue their passion without regard to race, color, religion, national or ethnic origin, gender, sexual orientation, gender identity or expression, age, disability, veteran status or any other characteristics protected by law.