COMPANY OVERVIEW:

At 1859, we are creating a pico-scale HTS platform (pico-HTS) that enables us to test millions of small molecule potential medicines in a single day and at an exponentially lower cost point compared to conventional HTS. At scale, our technology has the potential to usher in the promise of precision medicine and democratize the medicine discovery process. At 1859, we are committed to scientific integrity, discipline, objectivity, and openness. Our team consists of very talented chemists, assay biologists, material scientists, integration engineers, automation specialists and informaticians working closely together to bring our screening technology to the world.

We are comprised of high-performance engines, not cogs, and we invest in our people! Benefits include: paid holidays, PTO, a variety of medical plans, dental and vision insurance, a 401(k) plan, employee recognition awards, happy hours, company activities, and equity incentives. We are committed to training and career development for our people. Our goal is to provide a collaborative, data driven, productive and highly efficient company culture.

If you have a passion for changing the world of new medicine discovery, we encourage you to apply!

POSITION SUMMARY:

The successful candidate will be responsible for driving the development of novel biochemical assays both from external customers and for internal drug discovery programs to make them compatible with our microfluidics HTS platform. This role will require close collaboration work with systems engineers and production specialists. In our highly interconnected work environment, a team-player mentality and can-do attitude is essential. This position is 100% on-site at 1859 Inc.’s headquarters.

KEY RESPONSIBILITIES:

• Planning and performing experiments independently to develop mix and read assays for our microfluidics screening platform

• Collaborating with System Integration team to test and troubleshoot problems

• Presenting experimental data to peers and management in regular group meetings and cross-department update meetings

• Leading technology transfer efforts to Screening Integration team within given deadlines

• Leading development and validation of new methods and optimization of processes

• Performing general lab duties (e.g. ordering consumables, maintaining lab equipment, etc.)

• Maintaining accurate and complete records in electronic notebook

• Preparing and updating documentation as needed (SOPs, Batch Records, etc.)

• Being compliant with company policies, procedures, and safety regulations

REQUIREMENTS:

• Ph.D. in Biology, Biochemistry, Chemical Biology, Enzymology, or related discipline

• 0 - 3 years of relevant working experience in industry or post-doctoral research

• Previous experience in target discovery, assay development or HTS

• Previous experience with Prism and Microsoft Office Suite

• Aseptic laboratory technique and dexterity is required

• Detail-oriented with strong analytical and troubleshooting skills

• Demonstrated ability to work as part of a team and to adapt within a fast-changing environment

HIGHLY DESIRABLE:

Previous experience with:

• Python

• Chemical synthesis or solid-phase peptide synthesis