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ML/AI Scientist

1859

ML/AI Scientist

San Diego, CA
Full Time
Paid
  • Responsibilities

    COMPANY OVERVIEW:

    At 1859, we are creating a pico-scale HTS platform (pico-HTS) that enables us to test millions of small molecule potential medicines in a single day and at an exponentially lower cost point compared to conventional HTS. At scale, our technology has the potential to usher in the promise of precision medicine and democratize the medicine discovery process. At 1859, we are committed to scientific integrity, discipline, objectivity, and openness. Our team consists of very talented chemists, assay biologists, material scientists, integration engineers, automation specialists and informaticians working closely together to bring our screening technology to the world.

    We are comprised of high-performance engines, not cogs, and we invest in our people! Benefits include: paid holidays, PTO, a variety of medical plans, dental and vision insurance, a 401(k) plan, employee recognition awards, happy hours, company activities, and equity incentives. We are committed to training and career development for our people. Our goal is to provide a collaborative, data driven, productive and highly efficient company culture.

    If you have a passion for changing the world of new medicine discovery, we encourage you to apply!

    POSITION SUMMARY:

    You will turn in silico drug discovery into reality and unlock the next revolution in pharmacology. Your expertise in ML/AI together with your inquisitive mind will enable connecting molecular structures with compound properties (e.g. ADMET, physicochemical, and synthesizability profiling) to build both predictive and generative models. Ultimately these models will be used to  construct robust libraries of drug candidates for our internal screening and validation teams.

    KEY RESPONSIBILITIES:

    • Designing advanced ML/AI tools to drive synthesis of molecules

    • Implementing existing AI/ML tools to improve physio-chemical properties of hit molecules

    • Developing AI/ML tools to improve physio-chemical properties of hit, as well as lead molecules 

    • Developing ML methods to improve ADME/T properties of lead molecules

    • Designing and implementing tools to improve hit-to-lead pipeline

     

    REQUIREMENTS:

    • BS or MS in Computer Science, Computational Chemistry, Bioinformatics or related discipline

    • 3 - 5 years experience in ML/AI

    • Excellent programming skills

    • Excellent verbal and written communication skills

     

    HIGHLY DESIRABLE:

    • Practical experience developing and deploying solutions on cloud platforms

    • Strong understanding of software engineering best practices and full SDLC

    • Familiarity with public databases relevant to Bioinformatics and Cheminformatics

    • Experience with large databases and clustering methods

    • Familiarity with chemical databases

    • Interest in chemistry/pharmaceutical sciences