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remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health, and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio.

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2024 Genomic Research Center Oncology Genetics Intern Overview

Envision spending your summer working with energetic colleagues and inspirational leaders, all while gaining world-class experience in one of the most dynamic organizations in the pharmaceutical industry. This is a reality for AbbVie Interns.

This internship opportunity is a collaborative effort by the Computational Oncology and Methods Development groups within AbbVie’s Genomics Research Center. The Genomics Research Center (GRC) is a center of excellence for bioinformatics, functional genomics, human genetics, pharmacogenomics, and multiple population cohorts (over 1 million genomes) and works across all R&D, and other areas such as process sciences and corporate strategy. The GRC plays an integral role towards our goal of developing world class genetics and genomics research, focusing on finding the right targets and helping us better understand not only human disease biology but also the behavior of and response to our drugs in clinical trials.

Under co-supervision of two senior scientists from two collaborative groups, the intern will primarily analyze AbbVie’s Real-World-Data (RWD) omics population cohort in solid tumors to reveal associations between germline variants, demographic diversities, and treatment outcomes. The analysis aims to reveal racial, ethnic, and gender patterns of cancer susceptibility or drug resistance associated germline variants, and to evaluate how these diversities may impact cancer therapeutic response or adverse events. The intern’s project will inform strategies and recommendations to improve cancer care equity and diversity, which we believe is an imperative yet under-explored aspect of RWD genomics research.

Key responsibilities include:

• With intern managers, review literature and human genetics reference cohorts to generate an analysis plan for associating germline variants with demographic diversities,

• Collaborate with intern managers to process, quality control, and structuralize germline variant data from the internal RWD solid tumor cohort.

• Drive the analysis to test hypothesis of germline genetics diversity associated with race, ethnicity, and gender, and treatment outcome.

• Communicate and present the research progress to our internal RWD working group, computational oncology, and genomics community.

Minimum Qualifications

• Currently pursuing a Master’s or PhD degree in computational biology, genome biology, human genetics, biostatistics, computer science, or related fields.

• Hands-on experience with NGS data analysis and at least one general purpose data science language (R, Python, etc).

• Comfortable working with Linux and an on-premise high-performance computing environment.

• Must be enrolled in university for at least one semester following the internship.

Preferred Qualifications

• Experience with cancer genomics research.

• Experience with DNA-seq variant calling pipelines or method development.

• Experience with statistical genetics approaches (GWAS, QTL, etc).

• Familiarity with common population genetics cohorts such as UKBiobank or FinnGen.

• Demonstrated critical thinking and problem-solving capabilities.

• Self-motivated; ability to execute with limited supervision and direction. Can work independently.

• Expected graduation date between December 2024 - July 2025 .

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

• The salary range is: (minimum: $68,182.40 to maximum: $101,420.80)

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

Benefits and Amenities

• Competitive pay.

• Relocation support for eligible students.

• Opportunity to connect with AbbVie leaders and scientists.

• Exposure to Allergan Aesthetics portfolio and Medical Device Design control.

Equal Employment Opportunity

At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.

AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio.