Job Description
Job Title: Analytical Chemist – Oligonucleotides
Location: Boston, MA (Hybrid – 3 days onsite)
Duration: 12 months (extension possible)
Manager Notes
Strong preference towards 5 years of similar exp, candidate must be confident in a lab and with instrumentation and have experience with oligonucleotides. Looking for a candidate with commercial, analytical, and GMP exp. Candidate should be an analytical expert who can lead method transfer/validation independently.
Description:
The Analytical Chemist will join client's growing Technical Operations Analytical team and has the primary responsibility to provide analytical support for Oligonucleotides and Peptides in late-stage phase.
Key Responsibilities
- Provide analytical support for oligonucleotide and peptide–oligonucleotide conjugated compounds in late-stage development.
- Develop, optimize, and validate robust LC/MS, IP-RP-HPLC, and SAX-HPLC analytical methods for the analysis and purification of highly modified oligonucleotide drug substances.
- Perform analytical testing using IP-RP-HPLC, AX-HPLC, UPLC, LC-MS, and LC-MS/MS systems (Agilent, Waters, Thermo) and associated data software.
- Operate, maintain, and troubleshoot laboratory instrumentation to ensure accurate and reliable results.
- Ensure compliance with GLP/GMP standards in a regulated pharmaceutical environment.
- Author technical documents including protocols, reports, and method validation documents; effectively communicate findings across cross-functional teams.
- Work independently while collaborating with Technical Operations, Quality, and Manufacturing teams.
Qualifications
- BS or MS degree in Chemistry, Analytical Chemistry, or related field with 3+ years of relevant industry experience.
- Strong experience in analytical method development, optimization, transfer, and validation for oligonucleotide therapeutics.
- In-depth knowledge of mass spectrometry and purification techniques.
- Hands-on expertise in RP-HPLC, SAX-HPLC, UPLC, LC-MS, and related analytical platforms.
- Working knowledge of cGMP regulations and documentation practices.
- Strong technical writing, problem-solving, and cross-functional collaboration skills.