Join the team at Aro Biotherapeutics creating breakthrough biotherapeutics based on Centyrin oligonucleotide conjugates.  Centyrins are small protein domains based on the fibronectin domains of human Tenascin C that combine the affinity and specificity properties of antibodies with the stability and tissue penetration properties of small molecules.  We have engineered Centyrins with an array of specificities for normal and immune cell receptors.  By linking Centyrin domains together genetically, we have created multi-specific binders that retain a small footprint to enable excellent tissue penetration.  Engineered for high stability, multi-specific Centyrins are readily expressed and purified from E. coli or mammalian cells.

_We are developing a platform for delivery of an array of intracellularly active payloads with a focus on oligonucleotides.  Our team has built a strong set of in vitro and in vivo data validating the utility of Centyrins for receptor specific uptake in a variety of cell types.  Centyrin conjugate mediated delivery provides the foundation for access to a set of intracellular targets that have long been considered undruggable. _

Aro is building a wholly owned portfolio of Centyrin oligonucleotide conjugates for genetic and autoimmune diseases and developing a partnered portfolio of Centyrin conjugates for payload delivery in a variety of disease areas.  Led by an experienced and exceptional team, Aro is backed by an exceptional syndicate that supports our commitment to advancing drug candidates with the potential to improve patient's lives and to building an ideal environment for scientific and leadership growth.

POSITION DESCRIPTION – SCIENTIST, NUCLEIC ACID CHEMISTRY

Aro is expanding our Nucleic Acids Chemistry team to design and synthesize novel Centyrin-oligonucleotide conjugate based therapeutics. In this role, you will become a foundational member of the team. The ideal candidate will have a good understanding of how to design, synthesize, purify and quantify oligonucleotides. The position requires hands-on laboratory work and will be based in our Philadelphia location. Close collaboration with other members of the Aro team across protein engineering, chemistry and biology is essential. In this role, you will have the opportunity to contribute directly to efforts that support the company's portfolio of preclinical therapeutic candidates.

RESPONSIBILITIES

• Perform oligonucleotide synthesis from low milligram to gram scale
• Develop and execute clear synthetic strategies towards chemically modified oligonucleotide sequences using state-of-the-art synthetic methodologies.
• HPLC purification of synthesized siRNA and oligonucleotides
• LC/MS analysis of synthesized oligonucleotides
• Regularly present work to internal project teams and R&D Leadership
• Comply with laboratory safety procedures and maintain compliant laboratory records of experiments
• Routine maintenance of Mermade DNA/RNA synthesizer, LC/MS and LC systems

QUALIFICATIONS

• BS/MS in Chemistry or Life Science degree, with solid phase synthesis experience in oligonucleotides. 
  • Solid phase peptide synthesis experience will be considered
• Proficiency in the independent design and analysis of experiments. Significant understanding of data analysis, reproducibility and reliability of experimental data
• Demonstrated ability to work effectively in a collaborative team
• Strong communication skills, both written and oral with an ability to organize and communicate complex data sets in a clear and concise manner
• Proven track record of being personable, energetic, responsive, action-oriented, and accountable
• Experience in bioconjugation of oligonucleotides to proteins/peptides is a plus.

“Aro Biotherapeutics is an equal opportunity employer; all qualified applicants will be considered for employment without regard for any characteristic protected by law. Aro Biotherapeutics provides a competitive benefits package.”