VICE PRESIDENT, NUCLEIC ACID CHEMISTRY

PHILADELPHIA, PA; USA FULL TIME

COMPANY OVERVIEW

Join the team at Aro Biotherapeutics creating breakthrough biotherapeutics based on Centyrin oligonucleotide conjugates.  Centyrins are small protein domains based on the fibronectin domains of human Tenascin C that combine the affinity and specificity properties of antibodies with the stability and tissue penetration properties of small molecules.  We have engineered Centyrins with an array of specificities for normal and immune cell receptors.  Engineered for high stability in the absence of disulfides, multi-specific Centyrins are readily expressed and purified from E. coli or mammalian cells.  Conjugation of oligonucleotides is achieved by introduction of a unique cysteine at well characterized sites in the Centyrin backbone.

_We are developing a platform for delivery of an array of intracellularly active payloads with a focus on oligonucleotides.  Our team has built a strong set of in vitro and in vivo data validating the utility of Centyrins for receptor specific uptake in a variety of cell types.  Centyrin conjugate mediated delivery provides the foundation for access to a set of intracellular targets that have long been considered undruggable. _

Aro is building a wholly owned portfolio of Centyrin oligonucleotide conjugates for genetic and autoimmune diseases and developing a partnered portfolio of Centyrin conjugates for payload delivery in a variety of disease areas.  Led by an experienced and exceptional team, Aro is backed by an exceptional syndicate that supports our commitment to advancing drug candidates with the potential to improve patient's lives and to building an ideal environment for scientific and leadership growth.

JOB SUMMARY: VICE PRESIDENT, NUCLEIC ACID CHEMISTRY

We are seeking an oligonucleotide chemist with significant experience and expertise who can integrate into a fast-paced life sciences company that is advancing oligonucleotide Centyrin conjugates for serious diseases with unmet need. The successful candidate will possess a strong background in nucleic acid chemistry particularly as it relates to the design and synthesis of chemically modified siRNA and ASOs and will have experience in advancing drug candidates into development.  A track record of continuous advancement in roles of increasing responsibility for drug candidate nomination is required. Importantly, the VP of Chemistry will be responsible for building internal nucleic acid chemistry capabilities within Aro while also managing external chemistry activities. The position requires enthusiasm, passion, attention to detail and a desire to create new medicines for patients.

QUALIFICATIONS

• Ph.D. in Chemistry, with 7+ years of related experience in a pharmaceutical industry/biotech setting
• Experience in the design, preparation and purification of modified siRNA or ASOs
• Established knowledge in the area of design of pharmacologically active oligonucleotide therapies
• Experience in the synthesis of stabilized and derivatized siRNAs and ASOs is required
• An understanding of the basic pharmacology principles of nucleic acid therapies as they relate to efficacy, pharmacokinetics and toxicity is highly desired
• An innovator with track record in molecular design of novel oligonucleotide therapeutics with an ability to be creative and take a proactive approach to problem solving
• Ability and desire to work collaboratively on inter-disciplinary projects that span the chemical, analytical, and biological sciences.
• The candidate should have experience building and leading teams with excellent managerial skills
• Maintain high standards of laboratory safety
• The successful candidate will have strong interpersonal skills and a passion for science and the development of new, highly innovative technologies. In a growing and fast-paced environment, this individual must exhibit nimbleness, a willingness to step outside his or her comfort zone, a dedication to constant learning and personal development and thrive in a team environment. Good written and verbal communication skills are essential.

Aro Biotherapeutics is an equal opportunity employer; all qualified applicants will be considered for employment without regard for any characteristic protected by law. Aro Biotherapeutics provides a competitive benefits package.