COMPANY OVERVIEW

At Aro Biotherapeutics, we are focused on developing novel targeted Centyrin based medicines for serious human diseases.

Centyrins are a unique protein drug platform ideally suited for tissue or cell delivery of multiple drug payloads including nucleic acid drugs. Centyrins, a single domain protein engineered to combine the binding properties of antibodies with the biophysical properties of small molecules, represent a new approach to addressing diseases of high unmet need with molecular targets that have previously been ‘undruggable.' Utilizing this technology, we can specifically deliver siRNA and toxin payloads to extra-hepatic tissue using mono and bispecific targeting.

Aro Biotherapeutics was launched January 2018 and has office and has laboratory space in Cambridge Innovation Center in Philadelphia. Aro is advancing an exciting pipeline of Centyrin targeted therapeutics and collaborating with companies leading the field of targeted delivery.  Our goal is the be the leader in cell specific delivery of biomolecular therapeutics. 

JOB SUMMARY: INVESTIGATOR, BIOCONJUGATION

We are seeking an Investigator who can integrate into a fast-paced life sciences company that seeks to develop siRNA and toxin conjugates for serious diseases. The successful candidate will possess a strong background in bioconjugation approaches and have experience in protein purification and expression, as well as, the analytical characterization of bioconjugates. The position requires enthusiasm, passion, attention to detail and a desire to create new medicines for patients.

QUALIFICATIONS

• Ph.D. in Chemistry, Biology, Molecular Biology or related discipline, plus 2+ years of related experience in a pharmaceutical industry setting.
• Preparation and purification of bioconjugates (1 mg-1g) using modern protein purification methodologies such as FPLC (AKTA), tangential flow filtration (TFF), hydrophobic interaction chromatography (HIC), ion-exchange, affinity chromatography, and/or size-exclusion chromatography (SEC).
• Quantitatively and qualitatively analyze novel bioconjugates using methods such as UV/Vis, HPLC, CE-SDS, and LC-MS analysis using in-house equipment as well as coordinate and execute work through CROs and academic facilities.
• Established knowledge in the area of drug-conjugates; candidates will be familiar with and practiced in the synthesis and SAR of payloads and drug-linkers for use in ADCs or other protein conjugates.
• Experience working with stabilized and derivatized siRNAs is highly desired and a plus
• Knowledge of basic pharmacology principles and drug delivery.
• An innovator with track record in molecular design of biologics, of creative and proactive approach to problem solving, and strong analytical skills.
• Ability and desire to work collaboratively on inter-disciplinary projects that span the chemical, analytical, and biological sciences.
• Maintain high standards of laboratory safety and comply with all Aro's safety requirements.
• The successful candidate will have strong interpersonal skills and a passion for science and the development of new, highly innovative technologies. In a growing and fast-paced environment, this individual must exhibit nimbleness, a willingness to step outside his or her comfort zone, a dedication to constant learning and personal development and thrive in a team environment. Good written and verbal communication skills are essential.

Aro Biotherapeutics is an equal opportunity employer; all qualified applicants will be considered for employment without regard for any characteristic protected by law. Aro Biotherapeutics provides a competitive benefits package.