Investigator/Associate Scientist, Protein Engineering

COMPANY OVERVIEW

At Aro Biotherapeutics, we are focused on developing novel Centyrin targeted medicines for serious human diseases. We are looking to build our team with enthusiastic, rigorous, and motivated scientists.

Centyrins are a unique protein drug platform ideally suited for tissue or cell specific delivery of a variety of drug payloads including nucleic acid drugs. Centyrins area single domain proteins engineered to combine the binding properties of antibodies with the biophysical properties of small molecules and represent a new approach to addressing diseases of high unmet need with intracellular targets that have previously been ‘undruggable.' At Aro we are using Centyrins to enable access to intracellular targets in extra hepatic tissues combining chemical optimization of payloads with protein engineering expertise to create novel therapeutic candidates. Aro Biotherapeutics was launched in January 2018 and has office and laboratory space in Cambridge Innovation Center in Philadelphia.

THE POSITION

Reporting to the Head of Protein Engineering, the Associate Scientist will be part of a team applying protein engineering for optimization and characterization of therapeutic protein candidates.  In this role, the scientist will be responsible for generating, screening and characterization of protein libraries, developing screening assays, protein expression and purification. Molecular biology skills are essential. Experience with automation and high throughput screening is a plus. The Associate Scientist will interact with the scientific team and be expected to periodically present results at team meetings. Level will be commensurate with experience.

QUALIFICATIONS

BA/BS in biochemistry or related discipline and previous experience with molecular biology (in particular cloning/PCR), protein display technologies, protein expression and purification is required.  A familiarity with high throughput screening and methods for characterizing protein binding and protein stability are desirable.  Previous industry experience is a plus. Qualified candidates will be well-organized, able to work both independently and as part of a team, and able to meet deadlines in a fast-paced environment.

Aro Biotherapeutics is an equal opportunity employer; all qualified applicants will be considered for employment without regard for any characteristic protected by law. Aro Biotherapeutics provides a competitive benefits package.