COMPANY OVERVIEW

Join the team at Aro Biotherapeutics creating breakthrough biotherapeutics based on Centyrin oligonucleotide conjugates.  Centyrins are small protein domains based on the fibronectin domains of human Tenascin C that combine the affinity and specificity properties of antibodies with the stability and tissue penetration properties of small molecules.  We have engineered Centyrins with an array of specificities for normal and immune cell receptors.  By linking Centyrin domains together genetically, we have created multi-specific binders that retain a small footprint to enable excellent tissue penetration.  Engineered for high stability, multi-specific Centyrins are readily expressed and purified from E. coli or mammalian cells.

_We are developing a platform for delivery of an array of intracellularly active payloads with a focus on oligonucleotides.  Our team has built a strong set of in vitro and in vivo data validating the utility of Centyrins for receptor specific uptake in a variety of cell types.  Centyrin conjugate mediated delivery provides the foundation for access to a set of intracellular targets that have long been considered undruggable. _

Aro is building a wholly owned portfolio of Centyrin oligonucleotide conjugates for genetic and autoimmune diseases and developing a partnered portfolio of Centyrin conjugates for payload delivery in a variety of disease areas.  Led by an experienced and exceptional team, Aro is backed by an exceptional syndicate that supports our commitment to advancing drug candidates with the potential to improve patient's lives and to building an ideal environment for scientific and leadership growth.

JOB SUMMARY: SCIENTIST, BIOCONJUGATION

We are seeking an Associate scientist who can integrate into a fast-paced life sciences company that seeks to develop siRNA and toxin conjugates for serious diseases. The successful candidate will possess a strong background in chemistry and bioconjugation approaches and have experience performing bioconjugation reactions, protein purification and requisite analytical techniques. The position requires enthusiasm, passion, attention to detail and a desire to create new medicines for patients.

QUALIFICATIONS

• MS or BS (with 2-4 years experience) in Chemistry, Biology, Biochemistry or a related discipline, with preference for experience in a pharmaceutical/biotech setting.
• Hands-on experience with protein purification methodologies such as hydrophobic interaction chromatography (HIC), ion-exchange, affinity chromatography (IEX), and/or size-exclusion chromatography (SEC). Working knowledge of AKTA is highly desired
• Basic knowledge in the area of drug-conjugates; drug-linkers for use in ADCs or other protein conjugates.
• Ability and desire to work on inter-disciplinary projects that span the chemical, analytical, and biological sciences.
• Works creatively, proactively and collaboratively with other departments to support complex scientific projects.
• The successful candidate will have strong interpersonal skills and a passion for science and the development of new, highly innovative technologies. In a growing and fast-paced environment, this individual must exhibit nimbleness, a willingness to step outside his or her comfort zone, a dedication to constant learning and personal development and thrive in a team environment

JOB RESPONSIBILITIES

• Perform bioconjugate chemistry and purification with a focus on protein–small molecule / protein–peptide / protein - oligonucleotide / protein–fluorophore conjugates
• Plan and execute laboratory research and experimental design with minor supervision.
• Maintain a well-documented laboratory notebook.
• Maintain high standards of laboratory safety\ and comply with all Aro's safety requirements.
• Present results and experimental studies in group settings

Aro Biotherapeutics is an equal opportunity employer; all qualified applicants will be considered for employment without regard for any characteristic protected by law. Aro Biotherapeutics provides a competitive benefits package.