ABOUT ARO BIOTX

Join the team at Aro Biotherapeutics creating breakthrough biotherapeutics based on Centyrin oligonucleotide conjugates.  Centyrins are small protein domains based on the fibronectin domains of human Tenascin C that combine the affinity and specificity properties of antibodies with the stability and tissue penetration properties of small molecules.  We have engineered Centyrins with an array of specificities for normal and immune cell receptors.  By linking Centyrin domains together genetically, we have created multi-specific binders that retain a small footprint to enable excellent tissue penetration.  Engineered for high stability, multi-specific Centyrins are readily expressed and purified from E. coli or mammalian cells.

_We are developing a platform for delivery of an array of intracellularly active payloads with a focus on oligonucleotides.  Our team has built a strong set of in vitro and in vivo data validating the utility of Centyrins for receptor specific uptake in a variety of cell types.  Centyrin conjugate mediated delivery provides the foundation for access to a set of intracellular targets that have long been considered undruggable. _

Aro is building a wholly owned portfolio of Centyrin oligonucleotide conjugates for genetic and autoimmune diseases and developing a partnered portfolio of Centyrin conjugates for payload delivery in a variety of disease areas.  Led by an experienced and exceptional team, Aro is backed by an exceptional syndicate that supports our commitment to advancing drug candidates with the potential to improve patient's lives and to building an ideal environment for scientific and leadership growth.

JOB SUMMARY: SCIENTIST, BIOLOGY I-III

We are seeking a Scientist who can integrate into a fast-paced life sciences company that seeks to develop siRNA:centyrin conjugates for serious diseases. The successful candidate will possess a solid background in a biological area, including, but not limited to molecular biology, biochemistry, or cell biology.  Experience in RNA biology is a plus. The position requires enthusiasm, passion, attention to detail and a desire to create new medicines for patients.

QUALIFICATIONS

• MS or BS (level commensurate with experience) in Biology, Biochemistry or a related discipline, with preference for experience in a pharmaceutical/biotech setting.
• Laboratory experience in either an academic or industrial setting is essential
• Ability and desire to work on inter-disciplinary projects with other members of the company across different functional areas within biology and in chemistry and protein engineering
• The successful candidate will have strong interpersonal skills and a passion for science and the development of new, highly innovative technologies. In a growing and fast-paced environment, this individual must exhibit nimbleness, a willingness to step outside his or her comfort zone, a dedication to constant learning and personal development and thrive in a team environment

JOB RESPONSIBILITIES

• Develop an understanding of drug discovery and development
• Perform laboratory experiments focused on understanding basic mechanisms of siRNA biology
• Perform studies to advance drug discovery programs including assay design and assessment of early drug leads
• Develop or have proficiency in the independent design and analysis of experiments. Significant understanding of data analysis, reproducibility and reliability of experimental data
• Demonstrated ability to work effectively in a matrixed and highly collaborative team
• Strong communication skills, both written and oral with an ability to organize and communicate complex data sets in a clear and concise manner
• Proven track record of being personable, energetic, responsive, action-oriented, and accountable

Aro Biotherapeutics is an equal opportunity employer; all qualified applicants will be considered for employment without regard for any characteristic protected by law. Aro Biotherapeutics provides a competitive benefits package.