Job Description

** Position Summary: **

This role will support Antibody-drug conjugates (ADCs) linker and payload design, develop conjugation technologies, and downstream biochemical assays to enhance ADC biological and pharmacologic properties. We are looking for a strong scientist with good knowledge and hands-on experience in designing, preparing, and characterizing ADCs. This individual will be a self-motivated, responsible, and productive scientist who enjoys collaborating. They will be responsible for rigorous experimental design, data analysis, and data interpretation. This position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.

_ Responsibilities:_

• Prepare, purify, and characterize the high-quality antibody-conjugates (ADCs, ARCs, DACs etc.) with a high degree of independence in support of discovery and development of programs.
• Implement state of the art bioconjugation technologies (cysteine, lysine, site-specific and other) and utilizing other bioorthogonal chemistries to generate bioconjugates.
• Experienced in development of purification strategies (up to 100 mg) with affinity, ion-exchange, hydrophobic interaction, size exclusion, and tangential flow filtration.
• Maintain thorough documentation of experimental procedures in electronic notebook or database, writing of reports and technical documents.
• Engagement with multidisciplinary project teams to execute and interpret experiments.
• Participate and present periodic updates and reports to management team.
• Maintain a safe, pleasant, and efficient working environment.

Qualifications

_ Basic Requirements:_

• A minimum of a master’s degree in chemistry, biochemistry, or other related scientific discipline with a record of minimum 2 years in an industry lab-based independent research experience is required.
• Deep expertise in using state-of-the-art conjugation methods and handling of potent linker-payloads.
• Experienced in ADC characterization methods, including UV-Vis, SEC, HIC, RP, IEX, cIEF, and LC-MS.
• Must be eligible to work in the United States indefinitely without restriction or sponsorship.

_ Additional Preferences:_

• Experience with protein purification systems is preferred with hands-on experience and proficiency working with AKTA FPLCs.
• Must be highly collaborative and able to effectively engage small-molecule research project teams to make rapid progress.
• Demonstrated ability to work well with other accomplished professionals within and across functions/teams.
• Ability to multi-task and shift priorities rapidly to meet tight deadlines.
• Excellent written and verbal communicator.
• Detail oriented and well organized.
• Enthusiastic, self-motivated, and keen to improve processes.

Additional Information

Position is Full Time, Monday – Friday, 8am-5pm with overtime as needed . Candidates currently living within a commutable distance of Louisville, CO **** are encouraged to apply.

Excellent full-time benefits include:

• Comprehensive medical coverage, dental, and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holiday
• Yearly goal-based bonus & eligibility for merit-based increases
• Compensation: $75,000-$90,000 per year based on experience

Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.