Sorry, this listing is no longer accepting applications. Don’t worry, we have more awesome opportunities and internships for you.

VIRAL VECTOR TECHNICAL DEVELOPMENT RESEARCH ASSOCIATE/SRA

CARGO-Therapeutics

VIRAL VECTOR TECHNICAL DEVELOPMENT RESEARCH ASSOCIATE/SRA

San Mateo, CA
Full Time
Paid
  • Responsibilities

    CARGO Therapeutics is hiring a highly motivated Research Associate/Senior Research Associate to support viral vector process development and vector production for cell therapy products. The RA/SRA will contribute to and support development of GMP compatible manufacturing processes for production of CARGO's cell therapy products. The ideal candidate will have a background in virology, retro and/or lentiviral titering/transduction, cell culture, flow cytometry analysis, and vector copy number determinations.

    The successful candidate will work closely with the Process Sciences team and the broader CMC team. The individual will also collaborate cross-functionally to ensure timely development and manufacture, and release of vector/drug products as well as support regulatory submissions. The role is based in San Mateo, CA.

    WHAT YOU’LL DO AT CARGO 

    • Support planning and execution of experiments and associated analysis and reporting
    • Produce and characterize retroviral and lentiviral vectors for transduction of immune cells
    • Develop and optimize methods for production and characterization of high titer vector batches
    • Provide process development support for technical development studies performed both internally and externally
    • Support technology transfer to partners at external contract manufacturing organization including compilation of documentation (protocols, test methods, reports)
    • Participate in laboratory set up, equipment procurement, and establish internal process development practices
    • Author relevant documentation (protocols, technical development, qualification reports)
    • Organize, communicate, and present data to key stakeholders, senior management, and external partners
    • Interface and work collaboratively with CDMO and testing lab partners
    • Proactively enable cross-functional collaborations with internal stakeholders, external partners, and consultants.

    THE RIGHT STUFF

    PREFERRED QUALIFICATIONS:

    • Bachelors or Master’s degree in a relevant scientific area such as virology, biotechnology, bioprocess, molecular biology, immunology, biochemistry (required)
    • 2+ years of relevant experience in viral vector, T cell biology and/or immunotherapy
    • Prior experience in cell therapy, industry, process development preferred
    • Expertise in mammalian cell culture techniques such as transient transfection and viral vector production preferred
    • Experience in multi-color flow cytometry analysis preferred
    • Expertise in retro/lentiviral titering and qPCR/ddPCR techniques preferred
    • Ability to work in a highly adaptive environment and learn new skills for changing priorities
    • Flexible and creative, with ability to think outside the box
    • Must have interpersonal, organizational, written, and verbal communication skills, and the ability to work collaboratively in a team environment
    • Proficiency in Office, Design of Experiments, JMP, Prism, and other productivity and data analysis tools is a plus

    ABOUT CARGO 

    CARGO Therapeutics, formerly Syncopation Life Sciences, is advancing a new generation of adoptive cell therapies for cancers. Our cell therapies focus on addressing the primary mechanisms of failure, or resistance and relapse, to the currently available Chimeric Antigen Receptor T-cell (CAR T) therapies. Despite the advances made by existing autologous CAR T therapies, these treatments are only curative for less than half of all cancer patients, and therapeutic failure, resistance, and relapse are common. In addition, far too many patients are unable to access these potentially curative therapies due to barriers, including manufacturing, supply, time, and reimbursement challenges.

    CARGO is actively working to address these barriers with novel solutions that address the problems of resistance and access. Through smarter science, CARGO is developing and delivering CAR T-cell therapies to cure more patients. Focused on the delivery of complex therapeutic cargo, we enable the multiplex engineering necessary to overcome multiple mechanisms of tumor resistance, to counter inhibition by solid tumors, and in the allogeneic setting to evade immune rejection. From research to manufacturing to clinical care, we at CARGO aspire to disrupt the status quo to overcome resistance and maximize access to curative therapeutics.

    Join us to help make a difference.

    CARGO Therapeutics is committed to building a diverse, equitable, and inclusive company. We provide equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. CARGO Therapeutics also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requires of applicable law.

    CARGO Therapeutics requires all new hires to be fully vaccinated against COVID-19 as of their start date.  This requirement is a condition of employment at CARGO, and it applies regardless of whether the position is located at a CARGO site or is fully remote.  If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.