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Scientist I / II, Drug Discovery Technology Team

Carmot Therapeutics

Scientist I / II, Drug Discovery Technology Team

Berkeley, CA
Full Time
Paid
  • Responsibilities

    Carmot Therapeutics, Inc. is a biotech company focused on the discovery of innovative drugs for the treatment of metabolic diseases and cancer. Carmot is expanding the frontiers of drug discovery through application of its Chemotype Evolution platform to tackle challenging diseases. We have a broad pipeline and a portfolio of wholly-owned programs targeting class-B GPCRs and deubiquitinating enzymes, including our lead compound, CT-868, which is progressing toward Phase 2 clinical trials.

    Carmot is seeking a motivated researcher to join our Drug Discovery Technology Team and help leverage and expand exciting applications of the Chemotype Evolution platform. In this research position you will play a central role in applying Chemotype Evolution to identify and optimize novel drug leads for internal or partnered programs

    POSITION SUMMARY:

    You will perform high-throughput chemistries designed to produce custom screening libraries and will characterize these libraries using mass spectrometry. You will use high-throughput biological screening infrastructure to efficiently identify lead chemical matter and explore SAR, and develop techniques to explore covalent modification of proteins using mass spectrometry. Working closely with scientists in biology and chemistry as part of a multidisciplinary team, you will have to integrate diverse chemical and biological data to accelerate lead discovery. In this position you will be working in an exciting, innovative environment. The ideal candidate is a team-player, motivated by novel challenges and enthusiastically pursues creative solutions to achieve common goals.

    PRIMARY RESPONSIBILITIES:

    • Development, validation, and qualification of state-of-the-art mass spectrometry assays for the rapid analysis of compounds, peptides and proteins

    • Optimization of automated mass spectrometry data analysis and QC

    • Oversee mass spectrometry instrumentation operation, troubleshooting, and maintenance

    • Perform compound screening in biochemical and cell-based assays working with high-throughput workflows

    • Presentation of research progress at internal meetings and with external collaborators

    • Building diverse compound libraries using high-throughput automated techniques

    REQUIRED EXPERIENCE AND SKILLS:

    • PhD, or MS with industry experience, in biochemistry, chemical biology, chemistry or related field
    • High proficiency in mass-spectrometer operation
    • Prior experience with drug discovery and compound screening using biochemical and/or cell-based assays
    • Experience with robotics and assay automation is desirable
    • Experience with peptide mapping or proteomics is desirable
    • Ability and expertise to work within a multi-disciplinary team
    • Excellent communication, organization and data analysis skills

    Carmot offers competitive salary, participation in our stock option plan, and comprehensive benefits.

    Carmot Therapeutics, Inc. is committed to equal employment opportunity, regardless of age, ancestry, color, disability (mental and physical), exercising the right to family care and medical leave, gender, gender expression, gender identity, genetic information, marital status, medical condition, military or veteran status, national origin, political affiliation, race, religious creed, sex (includes pregnancy, childbirth, breastfeeding and related medical conditions), and sexual orientation.