Carmot Therapeutics, Inc., is a clinical-stage biotechnology company applying its proprietary drug discovery platform, Chemotype Evolution (CE), to discover and develop disease-modifying therapies in metabolic diseases and cancer. This position requires cross functional work within our biology, pharmacology, and chemistry teams. Our environment is exciting and fast paced, requiring you to be excellent at multitasking and easily adaptable to meet evolving goals. At Carmot we value diverse perspectives and encourage our scientists to contribute at multiple levels within the company, including strategic development.

Primary Responsibilities

• Produce membrane proteins in insect and mammalian expression systems to support structural biology efforts and biophysical/ biochemical assays.
• Perform biochemical/biophysical assays as necessary to ensure protein activity/folding.
• Perform structure determination of multiprotein complexes by cryo-EM single particle analysis.
• Support crystallization screening and optimize conditions of co-crystallization of protein-ligand complexes to produce high-quality crystals for X-ray diffraction.

Required Qualifications

• PhD in structural biology, biophysics, biochemistry or related discipline with 0-5 years of academic or industrial experience including at least 3 years of experience in the following:
  a. Insect (Sf9, Tni) and mammalian (HEK293, CHO) cell culture.
  b. Production of baculoviruses/ bacmam viruses including viral titer determination.
  c. Membrane protein expression in insect and mammalian cells.
  d. Protein purification using Akta systems, affinity and size-exclusion chromatography

• Ability to work in a diverse team setting.

• Excellent communication, interpersonal and organizational skills, including clear and consistent lab notebook-keeping.

Preferred Skills

• Experience in GPCR or other receptor complexes
• Experience in all aspects of structure determination by cryo-EM and protein crystallography

Carmot offers competitive salary, 401K retirement plan with company contribution, participation in our stock option plan, and comprehensive benefits. This position is located onsite in Berkeley, CA. Must be authorized to work for any employer in the U.S.

Annual base salary range:
Scientist I: 110k-120k
Scientist II: 120k - 140k

Carmot Therapeutics, Inc. is committed to equal employment opportunity, regardless of age, ancestry, color, disability (mental and physical), exercising the right to family care and medical leave, gender, gender expression, gender identity, genetic information, marital status, medical condition, military or veteran status, national origin, political affiliation, race, religious creed, sex (includes pregnancy, childbirth, breastfeeding and related medical conditions), and sexual orientation.