Deep Apple Therapeutics is a Bay Area biotechnology company with a focus on combining capabilities in molecular docking and structural biology to create a nucleus for accelerated drug discovery through advanced computer-aided drug design technologies. Deep Apple Therapeutics is applying a state-of-the-art technology research platform based on advanced computational modeling and large-scale compound docking (LSD), cryo-EM-based structural biology, and deep learning to drug discovery.

We are seeking highly motivated and energetic scientists to join a dynamic and well-funded research organization. Deep Apple Therapeutics offers a highly competitive compensation, equity, and benefits package.

Role Description

Our innovation and value-driven organization is seeking to hire an experienced Scientist to join our rapidly growing team. This position requires broad technical experience in biochemistry/structural biology related to G protein-coupled receptors (GPCRs), and a strong emphasis on an industrial mindset underpinned by critical thinking, multitasking, and the ability to propose new approaches and ideas.

Key Responsibilities

• Design and optimize the production of challenging protein targets for structural studies
• Establish state-of-the-art cryo-EM workflow including data collection, processing, and model building.
• Determine structures and co-structures of novel protein targets.
• Work closely with the computational biology and in vivo biology teams to iterate on compound progression.

Required Qualifications and Skills

• Ph.D. with at least 2 years of experience in biochemistry, biophysics, protein engineering, and/or structural biology with experience on multiple challenging membrane protein targets preferentially on GPCRs.
• Extensive experience with cryo-EM software, including data processing, visualization, and modeling (experience in crystallography is a plus).
• Design of constructs for protein expression, ability to generate and characterize suitable quantities of protein targets.
• Familiarity with cryo-EM data collection for structure determination. Experience with structure-guided drug discovery is a plus.
• Attention to detail with rigorous scientific thinking and clear communication supported by appropriate documentation.
• Creative mindset with a willingness to propose new approaches and ideas.