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The Chanda lab is interested in unraveling the molecular bases for these complex host-pathogen interactions. Viruses are obligate pathogens, and therefore their survival is dependent upon their ability to exploit host cellular machinery. Concurrently, viruses must also successfully evade immune surveillance mechanisms, including first-line (innate) defense systems. Specifically, we are studying cellular proteins required for both influenza A and retrovirus/HIV infection. additionally, we are investigating novel molecules that regulate, or respond to, Pattern Recognition Receptor (PRR) signaling. Taken together, we aim to elucidate the repertoire of host proteins required for viral infection, and understand the molecular strategies adapted by these viruses as countermeasures to innate immune responses. The scientists in the Chanda lab are also looking to find known drugs that can inhibit the Covid-19 virus. The approach they are taking, known as drug repositioning, can cut development time dramatically. Since they are looking at FDA-approved drugs that are proven to be safe in humans, these medicines could rapidly get to people infected with the virus. If successful, drug repositioning will likely be the fastest path to find a therapeutic solution for the virus. Visit the Chanda lab website to learn more: The Chanda Lab

VIEW THESE VIDEOS AND LINKS ON THE CURRENT RESEARCH IN THE CHANDA LAB: 

DISCOVERY OF SARS-COV-2 ANTIVIRAL DRUGS (NATURE)

COVID-19 ANTIBODY RESEARCH EFFORTS

MEET SCIENTISTS ON THE FRONT LINE WITH CORONAVIRUS

FINDING A DRUG FOR COVID-19

10 NEWS SUMIT CHANDA INTERVIEW

A RESEARCH ASSOCIATE I/II position is available in the Chanda Lab.They are seeking a highly self-motivated individual with a strong background in virology, mammalian cell culture and molecular biology, with an emphasis on respiratory viruses (SARS-CoV-2 and influenza) at both the BSL-2 and BSL-3 levels. The candidate will work in a highly dynamic and fast-paced environment.

Primary Responsibilities

• Perform in vitro and ex vivo infection assays, virus propagation and quantitation
• Perform cell-based screening, small molecule antiviral testing, siRNA and cDNA transfections, and tissue culture
• Maintain various mammalian cell lines and primary cells
• Perform basic molecular techniques such as cloning and DNA/RNA/protein works, and other related duties and tasks as required or assigned.Handling laboratory administration
• Overseeing equipment installation and maintenance
• Ordering and stocking of lab supplies
• Maintaining various reagent collections, and inventories
• Assisting with experiments as determined by the PI, and post-docs
• Keeping written record of experiments and data organization

Required Skills Required Experience

• BA/BS Degree in the biological sciences, chemistry, or a related field AND a minimum of 3 years of relevant experience OR MS degree in one of the biological sciences, chemistry or related field
• Candidates with 5+ years of experience would be considered for Level II
• Experience in assay development and high throughput genetic screening is desirable
• BSL-3 experience is highly desired

Knowledge, Skills and Abilities

• Ability to rapidly learn new research assays and process obtained data
• Ability to work independently as well as in a team environment
• Ability to be responsible, organized, and a problem solver
• Ability to manage multiple projects in a rapidly changing, deadline-driven environment
• Strong analytical, time management, organizational, and interpersonal skills
• Excellent verbal/written communication skills
• Ability to deliver mile-stones in timely manner
• Embody the Institute's core values of Commitment, Collaboration, Communication, Community and Compassion

The scientists at Sanford Burnham Prebys Medical Discovery Institute are making research breakthroughs in cancer, neuroscience, immunology, and children's disease. We are also at the forefront of finding solutions for emerging health threats such as COVID-19, where we are working to identify drugs that may help millions of people. During our more than 40 year history, we have established an NCI-designated Cancer Center, designed one of the most sophisticated drug discovery centers in the nonprofit world, and created global collaborations that are leading to preventions, treatments and cures to improve human health.  

Sanford-Burnham Medical Research Institute is an Equal Opportunity employer–M/F/Veteran/Disability.  We are committed to the hiring, advancement and fair treatment of all individuals and all qualified applicants will receive consideration for employment without regarding to race, color, religion, sex, national origin, sexual orientation, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law.  For additional information about your rights as an applicant, click HERE.