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LC/MS Protein Characterization Scientist

Eurofins USA BioPharma Services

LC/MS Protein Characterization Scientist

San Diego, CA
Full Time
Paid
  • Responsibilities

    Job Description

    • Familiar with protein structure and chemistry; experience handling proteins in a laboratory setting
    • Develop LCMS method for peptide mapping and disulfide mapping of proteins, antibodies and antibody-drug conjugates
    • Versed in proteolytic digestion procedures
    • Develop methods to identify the site occupancy of drugs in protein drug conjugates
    • Develop methods to identify post-translational modifications including deamidation and oxidation sites in proteins.
    • Develop methods to characterize glycoforms in glycoproteins
    • Develop mass spectroscopy methods for the determination of intact mass for proteins, peptides, and small molecules
    • Familiar with MSMS fragmentation of small molecules and peptides
    • Skilled at converting HPLC methods to LCMS compatible methods
    • Skilled in the operation of Waters QToF instruments and software (MassLynx)
    • Skilled at structural elucidation using accurate mass data
    • Skilled at developing HPLC and UPLC methods
  • Qualifications

    Qualifications

    • Applies GMP/GLP in all areas of responsibility, as appropriate
    • Applies the highest quality standard in all areas of responsibility
    • Demonstrates and promotes the company vision
    • Demonstrates strong client service skills, teamwork, and collaboration
    • Proactively plans and multitasks to maximize productivity
    • Meets all quality and productivity metrics and demonstrates strong teamwork and collaboration
    • Test serum samples from clinical drug development studies to determine drug level and anti-drug antibodies (ADA) in immunoassays to support high priority biological and vaccine programs
    • Work according to established Standard Operating Procedures (SOPs) and regulatory guidance
    • Maintain accurate records of ongoing projects in adherence with documentation standards
    • Assist in generation and review of reports and contribute to trouble shooting efforts
    • Work in a structured environment under limited to moderate supervision
    • Communicates effectively with client staff members
    • Conducts all activities in a safe and efficient manner

    QUALIFICATIONS

    • Minimum Bachelors or Masters degree in chemistry or other related science field and 4-5 years of laboratory experience in LC/MS.
    • PHD degree in related field with 1-2 years of experience with in LC/MS is allowed. 
    • Authorization to work in the United States indefinitely without restriction or sponsorship

    Additional Information

    Position is full-time, Monday - Friday 8:00am - 5:00pm. Candidates currently living within a commutable distance of San Diego, CA are encouraged to apply.

    • Excellent full time benefits including comprehensive medical coverage, dental, and vision options
    • Life and disability insurance
    • 401(k) with company match
    • Paid vacation and holidays

    EUROFINS IS A M/F, DISABLED, AND VETERAN EQUAL EMPLOYMENT OPPORTUNITY AND AFFIRMATIVE ACTION EMPLOYER.

    EUROFINS IS A M/F, DISABLED, AND VETERAN EQUAL EMPLOYMENT OPPORTUNITY AND AFFIRMATIVE ACTION EMPLOYER.