Job Description

We are seeking a scientist with a proven track record of cellular and molecular proteomics, analytical chemistry and/or biochemistry to play a key supporting role in the MS-based proteomics group in precision medicine and computational biology. The scientist will contribute to the development of LC-MS acquisition methods and proteomic workflows using robotics and automated liquid handlers with the outcome to accelerating and alleviating the manual-intensive aspects of sample prep increasing throughput and depth. The candidate will apply new and established workflows to biological systems and various sample types (tissues, biofluids and cells) for biomarker discovery and mechanism of action studies.

The candidate will work with cross-functional teams and across different therapeutic areas and academic collaborators on these projects.

Key responsibilities

• Contribute to innovative therapeutic platforms and apply cutting-edge proteomic technologies for disease profiling and biomarker discovery

• Generate proteomic datasets for disease profiling and mechanism of action studies

• Assist in instrument troubleshooting, maintenance and repairs

Qualifications

Minimum qualifications

• MS and 3+ years or equivalent, BS with 5+ years relevant lab experience in biochemistry, proteomics, analytical chemistry, or related field in academic, pharma or biotech industry, or PhD with 0-1 years postgraduate experience

• Hands-on experience with nano-flow LC-MS based proteomics (Label-free, DIA or TMT approaches)

• Hands-on experience with executing, optimizing, developing proteomic sample preparations (eg. extractions, SPE, digestion, peptide labeling protocols) from cells, tissues or biofluids for mass spec analysis

• Knowledge or experience with MS-data processing tools for proteomics (eg. Proteome Discoverer, Spectronaut), knowledge of biostatistics and bioinformatics

• Excellent communication and interpersonal skills to work in a collaborative environment

• Excellent organizational skills with the ability to multi-task on several projects

Preferred experience

• Sample preparation of limited tissue samples with Ultrasensitive proteomics

• Use, operation and/or maintenance of Thermo Orbitraps and/or Bruker Tims-Tof mass specs

• Hands-on operating and/or maintaining mass specs

• Hands-on targeted proteomic approaches

• Hands-on automation (liquid handlers, Hamilton, Bravo, Biomek)

• Hands-on co-immunoprecipitations, affinity-based protein profiling, chemoproteomics

• Analysis of proteomic data sets, coding experience in R or Phyton

Additional Information

• Position is full-time, Monday to Friday 8:00 am - 5:00 pm. Candidates currently living within a commutable distance of Cambridge, MA are encouraged to apply.

What we offer:

• Comprehensive medical coverage, with dental and vision options
• Life and disability insurance
• 401(k) with company match
• Paid holidays and vacation

Eurofins Lancaster Laboratories Professional Scientific Services® (PSS) is a global, award-winning insourcing solution that places our people at our clients’ site dedicated to running and managing laboratory services while eliminating headcount, co-employment and project-management worries.

Eurofins is a M/F, Disabled, and Veteran Equal Employment Opportunity and Affirmative Action employer.